Neuromodulation and hippocampal neurogenesis in depression: A scoping review
The ‘neurogenesis hypothesis of depression’ emphasizes the importance of upregulated hippocampal neurogenesis for the efficacy of antidepressant treatment. Neuromodulation is a promising therapeutic method that stimulates neural circuitries to treat neuropsychiatric illnesses. We conducted a scoping...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923022001721 |
| _version_ | 1797367837578231808 |
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| author | Angelo D. Flores Wing Shan Yu Man-Lung Fung Lee Wei Lim |
| author_facet | Angelo D. Flores Wing Shan Yu Man-Lung Fung Lee Wei Lim |
| author_sort | Angelo D. Flores |
| collection | DOAJ |
| description | The ‘neurogenesis hypothesis of depression’ emphasizes the importance of upregulated hippocampal neurogenesis for the efficacy of antidepressant treatment. Neuromodulation is a promising therapeutic method that stimulates neural circuitries to treat neuropsychiatric illnesses. We conducted a scoping review on the neurogenic and antidepressant outcomes of neuromodulation in animal models of depression. PubMed, Web of Science, and PsycInfo were comprehensively searched for full-text English articles from inception to October 5, 2021. Data screening and extraction were conducted independently by two researchers. Seventeen eligible studies were included in this review. The majority of studies used non-invasive neuromodulation (n = 14) and assessed neurogenesis using neural proliferation (n = 16) and differentiation markers (n = 9). Limited reports (n = 2) used neurogenic inhibitors to evaluate the role of neurogenesis on the depressive-like behavioral outcomes. Overall, neuromodulation substantially effectuated both hippocampal cell proliferation and antidepressant-like behavior in animal models of depression, with some providing evidence for enhanced neuronal differentiation and maturation. The proposed neurogenic-related mechanisms mediating the neuromodulation efficacies included neurotrophic processes, anti-apoptotic pathways, and normalization of HPA axis functions. Further research is warranted to explore the role of neuromodulation-induced neurogenic effects on treatment efficacies and to elucidate the underlying molecular mechanisms. |
| first_indexed | 2024-03-08T17:22:50Z |
| format | Article |
| id | doaj.art-8c22367d5e3c4a2689451f1bce78a065 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-08T17:22:50Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-8c22367d5e3c4a2689451f1bce78a0652024-01-03T04:11:35ZengElsevierBrain Research Bulletin1873-27472022-10-0118892107Neuromodulation and hippocampal neurogenesis in depression: A scoping reviewAngelo D. Flores0Wing Shan Yu1Man-Lung Fung2Lee Wei Lim3School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionCorrespondence to: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, L4 Laboratory Block, 21 Sassoon Road, Hong Kong Special Administrative Region.; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionCorrespondence to: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, L4 Laboratory Block, 21 Sassoon Road, Hong Kong Special Administrative Region.; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionThe ‘neurogenesis hypothesis of depression’ emphasizes the importance of upregulated hippocampal neurogenesis for the efficacy of antidepressant treatment. Neuromodulation is a promising therapeutic method that stimulates neural circuitries to treat neuropsychiatric illnesses. We conducted a scoping review on the neurogenic and antidepressant outcomes of neuromodulation in animal models of depression. PubMed, Web of Science, and PsycInfo were comprehensively searched for full-text English articles from inception to October 5, 2021. Data screening and extraction were conducted independently by two researchers. Seventeen eligible studies were included in this review. The majority of studies used non-invasive neuromodulation (n = 14) and assessed neurogenesis using neural proliferation (n = 16) and differentiation markers (n = 9). Limited reports (n = 2) used neurogenic inhibitors to evaluate the role of neurogenesis on the depressive-like behavioral outcomes. Overall, neuromodulation substantially effectuated both hippocampal cell proliferation and antidepressant-like behavior in animal models of depression, with some providing evidence for enhanced neuronal differentiation and maturation. The proposed neurogenic-related mechanisms mediating the neuromodulation efficacies included neurotrophic processes, anti-apoptotic pathways, and normalization of HPA axis functions. Further research is warranted to explore the role of neuromodulation-induced neurogenic effects on treatment efficacies and to elucidate the underlying molecular mechanisms.http://www.sciencedirect.com/science/article/pii/S0361923022001721NeuromodulationAdult hippocampal neurogenesisCell proliferationDepressionAntidepressant |
| spellingShingle | Angelo D. Flores Wing Shan Yu Man-Lung Fung Lee Wei Lim Neuromodulation and hippocampal neurogenesis in depression: A scoping review Brain Research Bulletin Neuromodulation Adult hippocampal neurogenesis Cell proliferation Depression Antidepressant |
| title | Neuromodulation and hippocampal neurogenesis in depression: A scoping review |
| title_full | Neuromodulation and hippocampal neurogenesis in depression: A scoping review |
| title_fullStr | Neuromodulation and hippocampal neurogenesis in depression: A scoping review |
| title_full_unstemmed | Neuromodulation and hippocampal neurogenesis in depression: A scoping review |
| title_short | Neuromodulation and hippocampal neurogenesis in depression: A scoping review |
| title_sort | neuromodulation and hippocampal neurogenesis in depression a scoping review |
| topic | Neuromodulation Adult hippocampal neurogenesis Cell proliferation Depression Antidepressant |
| url | http://www.sciencedirect.com/science/article/pii/S0361923022001721 |
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