Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method

Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method

Abstract Background Cerebral amyloid angiopathy (CAA) occurs in 80% of patients with Alzheimer’s disease (AD) and is mainly caused by the abnormal deposition of Aβ in the walls of cerebral blood vessels. Cerebrovascular molecular mechanisms in CAA were investigated by using comprehensive and accurat...

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Bibliographic Details
Main Authors: Takumi Handa, Hayate Sasaki, Masaki Takao, Mitsutoshi Tano, Yasuo Uchida
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Fluids and Barriers of the CNS
Subjects:
CAA
Fibrosis
Aβ
Apoptosis
SWATH
Online Access:https://doi.org/10.1186/s12987-022-00351-x

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