Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells

Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells

Glioblastoma (GBM) is the most advanced and aggressive form of gliomas. Dihydroartemisinin (DHA) has been shown to exhibit anti-tumor activity in various cancer cells. However, the effect and molecular mechanisms underlying its anti-tumor activity in human GBM cells remain to be elucidated. Our resu...

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Detalhes bibliográficos
Principais autores: Chengbin Qu, Jun Ma, Xiaobai Liu, Yixue Xue, Jian Zheng, Libo Liu, Jing Liu, Zhen Li, Lei Zhang, Yunhui Liu
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2017-09-01
coleção:Frontiers in Cellular Neuroscience
Assuntos:
dihydroartemisinin
reactive oxygen species
mitochondrion
endoplasmic reticulum
apoptosis
autophagy
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fncel.2017.00310/full

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