Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case Report
Xiao Xiao,1 Hongpan Tian,1 Xiaohuan Cheng,1 Guoming Li,2 Junying Zhou,1 Zhiyong Peng,3 Yirong Li1 1Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Health Inspection and Testing Institute, Hubei Provincial Center for Disease Cont...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-10-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/pandoraea-sputorum-bacteremia-in-a-patient-who-had-undergone-allogenei-peer-reviewed-article-IDR |
| _version_ | 1819048661589426176 |
|---|---|
| author | Xiao X Tian H Cheng X Li G Zhou J Peng Z Li Y |
| author_facet | Xiao X Tian H Cheng X Li G Zhou J Peng Z Li Y |
| author_sort | Xiao X |
| collection | DOAJ |
| description | Xiao Xiao,1 Hongpan Tian,1 Xiaohuan Cheng,1 Guoming Li,2 Junying Zhou,1 Zhiyong Peng,3 Yirong Li1 1Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Health Inspection and Testing Institute, Hubei Provincial Center for Disease Control and Prevention, Wuhan, People’s Republic of China; 3Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of ChinaCorrespondence: Yirong LiDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, People’s Republic of ChinaTel +86 02767812570Email liyirong838@163.comZhiyong PengDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, People’s Republic of ChinaTel +86 02767811807Email pengzy5@hotmail.comAbstract: Pandoraea sputorum (P. sputorum), an emerging pathogen, is able to trigger a pronounced pro-inflammatory response that results in lung dysfunction in cystic fibrosis (CF) patients. All previous P. sputorum isolates have been obtained from the respiratory samples of CF patients, with no reported cases of P. sputorum bacteremia. For the first time, we report P. sputorum isolates recovered twice from the blood cultures of a patient with liver cancer who had undergone allogeneic liver transplantation. These isolates were successfully identified by combining mass spectrometry and molecular techniques based on 16S rRNA sequencing methods. At the onset of the P. sputorum bacteremia, the patient’s peripheral T, B and NK cell counts were 181.68/μL, 59.57/μL and 70.66/μL, respectively. The serum procalcitonin level, C-reactive protein level and peripheral neutrophil granulocyte percentage were 0.56 ng/mL, 61.00 mg/L and 96.8%, respectively. We found these isolates to be susceptible to ciprofloxacin and piperacillin/tazobactam and to be intermediate to amikacin. Previous studies have found P. sputorum isolates to be resistant. All of the data combined showed that compromised immune function from allogeneic liver transplantation plus immunosuppressive therapy contributes to the occurrence of P. sputorum bacteremia. Furthermore, the P. sputorum isolates demonstrated characteristic resistance profiles.Keywords: Pandoraea sputorum, bacteremia, liver cancer, allogeneic liver transplantation |
| first_indexed | 2024-12-21T11:19:48Z |
| format | Article |
| id | doaj.art-8c24c978c24b425888338649bf9261a0 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-21T11:19:48Z |
| publishDate | 2019-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-8c24c978c24b425888338649bf9261a02022-12-21T19:05:48ZengDove Medical PressInfection and Drug Resistance1178-69732019-10-01Volume 123359336449350Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case ReportXiao XTian HCheng XLi GZhou JPeng ZLi YXiao Xiao,1 Hongpan Tian,1 Xiaohuan Cheng,1 Guoming Li,2 Junying Zhou,1 Zhiyong Peng,3 Yirong Li1 1Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Health Inspection and Testing Institute, Hubei Provincial Center for Disease Control and Prevention, Wuhan, People’s Republic of China; 3Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of ChinaCorrespondence: Yirong LiDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, People’s Republic of ChinaTel +86 02767812570Email liyirong838@163.comZhiyong PengDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, People’s Republic of ChinaTel +86 02767811807Email pengzy5@hotmail.comAbstract: Pandoraea sputorum (P. sputorum), an emerging pathogen, is able to trigger a pronounced pro-inflammatory response that results in lung dysfunction in cystic fibrosis (CF) patients. All previous P. sputorum isolates have been obtained from the respiratory samples of CF patients, with no reported cases of P. sputorum bacteremia. For the first time, we report P. sputorum isolates recovered twice from the blood cultures of a patient with liver cancer who had undergone allogeneic liver transplantation. These isolates were successfully identified by combining mass spectrometry and molecular techniques based on 16S rRNA sequencing methods. At the onset of the P. sputorum bacteremia, the patient’s peripheral T, B and NK cell counts were 181.68/μL, 59.57/μL and 70.66/μL, respectively. The serum procalcitonin level, C-reactive protein level and peripheral neutrophil granulocyte percentage were 0.56 ng/mL, 61.00 mg/L and 96.8%, respectively. We found these isolates to be susceptible to ciprofloxacin and piperacillin/tazobactam and to be intermediate to amikacin. Previous studies have found P. sputorum isolates to be resistant. All of the data combined showed that compromised immune function from allogeneic liver transplantation plus immunosuppressive therapy contributes to the occurrence of P. sputorum bacteremia. Furthermore, the P. sputorum isolates demonstrated characteristic resistance profiles.Keywords: Pandoraea sputorum, bacteremia, liver cancer, allogeneic liver transplantationhttps://www.dovepress.com/pandoraea-sputorum-bacteremia-in-a-patient-who-had-undergone-allogenei-peer-reviewed-article-IDRPandoraea sputorumbacteremialiver cancerallogeneic liver transplantation |
| spellingShingle | Xiao X Tian H Cheng X Li G Zhou J Peng Z Li Y Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case Report Infection and Drug Resistance Pandoraea sputorum bacteremia liver cancer allogeneic liver transplantation |
| title | Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case Report |
| title_full | Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case Report |
| title_fullStr | Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case Report |
| title_full_unstemmed | Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case Report |
| title_short | Pandoraea sputorum Bacteremia In A Patient Who Had Undergone Allogeneic Liver Transplantation Plus Immunosuppressive Therapy: A Case Report |
| title_sort | pandoraea sputorum bacteremia in a patient who had undergone allogeneic liver transplantation plus immunosuppressive therapy a case report |
| topic | Pandoraea sputorum bacteremia liver cancer allogeneic liver transplantation |
| url | https://www.dovepress.com/pandoraea-sputorum-bacteremia-in-a-patient-who-had-undergone-allogenei-peer-reviewed-article-IDR |
| work_keys_str_mv | AT xiaox pandoraeasputorumbacteremiainapatientwhohadundergoneallogeneiclivertransplantationplusimmunosuppressivetherapyacasereport AT tianh pandoraeasputorumbacteremiainapatientwhohadundergoneallogeneiclivertransplantationplusimmunosuppressivetherapyacasereport AT chengx pandoraeasputorumbacteremiainapatientwhohadundergoneallogeneiclivertransplantationplusimmunosuppressivetherapyacasereport AT lig pandoraeasputorumbacteremiainapatientwhohadundergoneallogeneiclivertransplantationplusimmunosuppressivetherapyacasereport AT zhouj pandoraeasputorumbacteremiainapatientwhohadundergoneallogeneiclivertransplantationplusimmunosuppressivetherapyacasereport AT pengz pandoraeasputorumbacteremiainapatientwhohadundergoneallogeneiclivertransplantationplusimmunosuppressivetherapyacasereport AT liy pandoraeasputorumbacteremiainapatientwhohadundergoneallogeneiclivertransplantationplusimmunosuppressivetherapyacasereport |