Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early life
<p>Abstract</p> <p>Background</p> <p>Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examine...
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | BMC Public Health |
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| Online Access: | http://www.biomedcentral.com/1471-2458/12/659 |
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| author | Poole Elizabeth M Tworoger Shelley S Hankinson Susan E Baer Heather J |
| author_facet | Poole Elizabeth M Tworoger Shelley S Hankinson Susan E Baer Heather J |
| author_sort | Poole Elizabeth M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examined the role of <it>IGF-1</it> and <it>IGFBP-3</it> genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size.</p> <p>Methods</p> <p>We examined whether htSNPs in <it>IGF-1</it> and the <it>IGFBP-1</it>/<it>IGFBP-3</it> gene region are associated with the self-reported outcomes of birthweight, body fatness at ages 5 and 10, and body mass index (BMI) at age 18 among healthy women from the Nurses’ Health Study (NHS) and NHSII. We used ordinal logistic regression to model odds ratios (ORs) and 95% confidence intervals (CI) of a one category increase for birthweight and somatotypes at ages 5 and 10. We used linear regression to model associations with BMI at age 18.</p> <p>Results</p> <p>Among 4567 healthy women in NHS and NHSII, we observed no association between common <it>IGF-1</it> or <it>IGFBP-1</it>/<it>IGFBP-3</it> SNPs and birthweight, body fatness at ages 5 and 10, or BMI at age 18.</p> <p>Conclusions</p> <p>Common <it>IGF-1</it> and <it>IGFBP-1</it>/<it>IGFBP-3</it> SNPs are not associated with body size in early life.</p> |
| first_indexed | 2024-04-12T14:23:19Z |
| format | Article |
| id | doaj.art-8c264ae7742b4ebda2f0461932a2cc87 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-12T14:23:19Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-8c264ae7742b4ebda2f0461932a2cc872022-12-22T03:29:30ZengBMCBMC Public Health1471-24582012-08-0112165910.1186/1471-2458-12-659Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early lifePoole Elizabeth MTworoger Shelley SHankinson Susan EBaer Heather J<p>Abstract</p> <p>Background</p> <p>Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examined the role of <it>IGF-1</it> and <it>IGFBP-3</it> genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size.</p> <p>Methods</p> <p>We examined whether htSNPs in <it>IGF-1</it> and the <it>IGFBP-1</it>/<it>IGFBP-3</it> gene region are associated with the self-reported outcomes of birthweight, body fatness at ages 5 and 10, and body mass index (BMI) at age 18 among healthy women from the Nurses’ Health Study (NHS) and NHSII. We used ordinal logistic regression to model odds ratios (ORs) and 95% confidence intervals (CI) of a one category increase for birthweight and somatotypes at ages 5 and 10. We used linear regression to model associations with BMI at age 18.</p> <p>Results</p> <p>Among 4567 healthy women in NHS and NHSII, we observed no association between common <it>IGF-1</it> or <it>IGFBP-1</it>/<it>IGFBP-3</it> SNPs and birthweight, body fatness at ages 5 and 10, or BMI at age 18.</p> <p>Conclusions</p> <p>Common <it>IGF-1</it> and <it>IGFBP-1</it>/<it>IGFBP-3</it> SNPs are not associated with body size in early life.</p>http://www.biomedcentral.com/1471-2458/12/659IGF-1IGFBP-1IGFBP-3BirthweightBody sizeAdolescence |
| spellingShingle | Poole Elizabeth M Tworoger Shelley S Hankinson Susan E Baer Heather J Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early life BMC Public Health IGF-1 IGFBP-1 IGFBP-3 Birthweight Body size Adolescence |
| title | Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early life |
| title_full | Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early life |
| title_fullStr | Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early life |
| title_full_unstemmed | Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early life |
| title_short | Genetic variability in <it>IGF-1</it> and <it>IGFBP-3</it> and body size in early life |
| title_sort | genetic variability in it igf 1 it and it igfbp 3 it and body size in early life |
| topic | IGF-1 IGFBP-1 IGFBP-3 Birthweight Body size Adolescence |
| url | http://www.biomedcentral.com/1471-2458/12/659 |
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