NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
This study provided normal tissue complication probability (NTCP) calculations from photon radiotherapy techniques in eleven patients with thymoma. Five plans were created for each participant using three-dimensional conformal radiotherapy (3D-CRT), five-field intensity modulated radiotherapy (5F-IM...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/8/561 |
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| author | Michalis Mazonakis Stefanos Kachris Maria Tolia John Damilakis |
| author_facet | Michalis Mazonakis Stefanos Kachris Maria Tolia John Damilakis |
| author_sort | Michalis Mazonakis |
| collection | DOAJ |
| description | This study provided normal tissue complication probability (NTCP) calculations from photon radiotherapy techniques in eleven patients with thymoma. Five plans were created for each participant using three-dimensional conformal radiotherapy (3D-CRT), five-field intensity modulated radiotherapy (5F-IMRT), seven-field IMRT (7F-IMRT), and volumetric modulated arc therapy with full arcs (FA-VMAT) and partial arcs (PA-VMAT). The target coverage, homogeneity index and conformation number for the planning target volume (PTV) and dosimetric parameters for the organs-at-risk (OARs) were taken from the fifty-five generated plans. The patient-specific NTCP of the lungs, heart and esophagus was calculated with an in-house software tool using differential dose-volume histograms and the equivalent uniform dose model. The PTV dose metrics from 3D-CRT were inferior to those from IMRT and VMAT plans. The dose constraints for the OARs were met in all treatment plans. The NTCP range of the lungs, heart and esophagus was 0.34–0.49%, 0.03–0.06% and 0.08–0.10%, respectively. The NTCPs of the heart for the incidence of peridarditis from IMRT and VMAT were significantly smaller than those from conformal treatment (<i>p</i> < 0.05). The 7F-IMRT was significantly superior to FA-VMAT in reducing the NTCP of the lungs and the risk of pneumonitis (<i>p</i> = 0.001). Similar superiority of 5F-IMRT over PA-VMAT for lung protection was found (<i>p</i> = 0.009). The presented results may be employed in the selection of the appropriate irradiation technique for restricting the complications in the adjacent OARs. |
| first_indexed | 2024-03-11T00:00:24Z |
| format | Article |
| id | doaj.art-8c29755f0bf4439688bcf6c197631c4e |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T00:00:24Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-8c29755f0bf4439688bcf6c197631c4e2023-11-19T00:46:53ZengMDPI AGCurrent Oncology1198-00521718-77292023-08-013087740775210.3390/curroncol30080561NTCP Calculations of Five Different Irradiation Techniques for the Treatment of ThymomaMichalis Mazonakis0Stefanos Kachris1Maria Tolia2John Damilakis3Department of Medical Physics, Faculty of Medicine, University of Crete, 71003 Iraklion, GreeceDepartment of Radiotherapy and Oncology, University Hospital of Iraklion, 71110 Iraklion, GreeceDepartment of Radiotherapy and Oncology, University Hospital of Iraklion, 71110 Iraklion, GreeceDepartment of Medical Physics, Faculty of Medicine, University of Crete, 71003 Iraklion, GreeceThis study provided normal tissue complication probability (NTCP) calculations from photon radiotherapy techniques in eleven patients with thymoma. Five plans were created for each participant using three-dimensional conformal radiotherapy (3D-CRT), five-field intensity modulated radiotherapy (5F-IMRT), seven-field IMRT (7F-IMRT), and volumetric modulated arc therapy with full arcs (FA-VMAT) and partial arcs (PA-VMAT). The target coverage, homogeneity index and conformation number for the planning target volume (PTV) and dosimetric parameters for the organs-at-risk (OARs) were taken from the fifty-five generated plans. The patient-specific NTCP of the lungs, heart and esophagus was calculated with an in-house software tool using differential dose-volume histograms and the equivalent uniform dose model. The PTV dose metrics from 3D-CRT were inferior to those from IMRT and VMAT plans. The dose constraints for the OARs were met in all treatment plans. The NTCP range of the lungs, heart and esophagus was 0.34–0.49%, 0.03–0.06% and 0.08–0.10%, respectively. The NTCPs of the heart for the incidence of peridarditis from IMRT and VMAT were significantly smaller than those from conformal treatment (<i>p</i> < 0.05). The 7F-IMRT was significantly superior to FA-VMAT in reducing the NTCP of the lungs and the risk of pneumonitis (<i>p</i> = 0.001). Similar superiority of 5F-IMRT over PA-VMAT for lung protection was found (<i>p</i> = 0.009). The presented results may be employed in the selection of the appropriate irradiation technique for restricting the complications in the adjacent OARs.https://www.mdpi.com/1718-7729/30/8/561thymoma3D-CRTIMRTVMATNTCP |
| spellingShingle | Michalis Mazonakis Stefanos Kachris Maria Tolia John Damilakis NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma Current Oncology thymoma 3D-CRT IMRT VMAT NTCP |
| title | NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma |
| title_full | NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma |
| title_fullStr | NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma |
| title_full_unstemmed | NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma |
| title_short | NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma |
| title_sort | ntcp calculations of five different irradiation techniques for the treatment of thymoma |
| topic | thymoma 3D-CRT IMRT VMAT NTCP |
| url | https://www.mdpi.com/1718-7729/30/8/561 |
| work_keys_str_mv | AT michalismazonakis ntcpcalculationsoffivedifferentirradiationtechniquesforthetreatmentofthymoma AT stefanoskachris ntcpcalculationsoffivedifferentirradiationtechniquesforthetreatmentofthymoma AT mariatolia ntcpcalculationsoffivedifferentirradiationtechniquesforthetreatmentofthymoma AT johndamilakis ntcpcalculationsoffivedifferentirradiationtechniquesforthetreatmentofthymoma |