Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia
Abstract The aim is to study the intraocular pressure (IOP)-lowering effects of additional administration of ripasudil in open-angle glaucoma (OAG) patients including high myopia (HM) and pathological myopia (PM). Study design is retrospective cohort study. We assessed the changes in the mean IOP be...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49782-y |
| _version_ | 1797376989044146176 |
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| author | Takeshi Yoshida Sota Yoshimoto Takuhei Nomura Taiju Ito Motohisa Ohno Shintaro Yasuda Yuto Shiotani Kyoko Ohno-Matsui |
| author_facet | Takeshi Yoshida Sota Yoshimoto Takuhei Nomura Taiju Ito Motohisa Ohno Shintaro Yasuda Yuto Shiotani Kyoko Ohno-Matsui |
| author_sort | Takeshi Yoshida |
| collection | DOAJ |
| description | Abstract The aim is to study the intraocular pressure (IOP)-lowering effects of additional administration of ripasudil in open-angle glaucoma (OAG) patients including high myopia (HM) and pathological myopia (PM). Study design is retrospective cohort study. We assessed the changes in the mean IOP between the HM eyes (axial length ≧ 26.5 mm 33 eyes) and the non-HM eyes (axial length < 26.5 mm 29 eyes) at 4 and 12 weeks from baseline. We also assessed the IOP changes between the PM eyes (21 eyes) and the non-PM eyes (41 eyes). The significant IOP reduction by the ripasudil administration was observed at 4 weeks in the non-HM eyes and at 12 weeks in HM and non-HM eyes. And the IOP reduction in the HM eyes was significantly less than the non-HM eyes at 4 and 12 weeks. IOP reduction by ripasudil had statistically significant association with the baseline IOP and presence of PM. Furthermore, significant IOP reduction by the ripasudil administration was observed at 4 and 12 weeks in the non-PM eyes, but not in the PM eyes. The additional administration of ripasudil was effective in the HM eyes, but less than non-HM eyes. And the PM may negatively contribute to reducing the IOP by ripasudil. |
| first_indexed | 2024-03-08T19:46:29Z |
| format | Article |
| id | doaj.art-8c29949f939c46d9807f7357c61623a9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T19:46:29Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8c29949f939c46d9807f7357c61623a92023-12-24T12:19:47ZengNature PortfolioScientific Reports2045-23222023-12-011311910.1038/s41598-023-49782-yIntraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopiaTakeshi Yoshida0Sota Yoshimoto1Takuhei Nomura2Taiju Ito3Motohisa Ohno4Shintaro Yasuda5Yuto Shiotani6Kyoko Ohno-Matsui7Department of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental UniversityAbstract The aim is to study the intraocular pressure (IOP)-lowering effects of additional administration of ripasudil in open-angle glaucoma (OAG) patients including high myopia (HM) and pathological myopia (PM). Study design is retrospective cohort study. We assessed the changes in the mean IOP between the HM eyes (axial length ≧ 26.5 mm 33 eyes) and the non-HM eyes (axial length < 26.5 mm 29 eyes) at 4 and 12 weeks from baseline. We also assessed the IOP changes between the PM eyes (21 eyes) and the non-PM eyes (41 eyes). The significant IOP reduction by the ripasudil administration was observed at 4 weeks in the non-HM eyes and at 12 weeks in HM and non-HM eyes. And the IOP reduction in the HM eyes was significantly less than the non-HM eyes at 4 and 12 weeks. IOP reduction by ripasudil had statistically significant association with the baseline IOP and presence of PM. Furthermore, significant IOP reduction by the ripasudil administration was observed at 4 and 12 weeks in the non-PM eyes, but not in the PM eyes. The additional administration of ripasudil was effective in the HM eyes, but less than non-HM eyes. And the PM may negatively contribute to reducing the IOP by ripasudil.https://doi.org/10.1038/s41598-023-49782-y |
| spellingShingle | Takeshi Yoshida Sota Yoshimoto Takuhei Nomura Taiju Ito Motohisa Ohno Shintaro Yasuda Yuto Shiotani Kyoko Ohno-Matsui Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia Scientific Reports |
| title | Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia |
| title_full | Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia |
| title_fullStr | Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia |
| title_full_unstemmed | Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia |
| title_short | Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia |
| title_sort | intraocular pressure lowering effects of ripasudil on open angle glaucoma in eyes with high myopia and pathological myopia |
| url | https://doi.org/10.1038/s41598-023-49782-y |
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