Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities
Pancreatic cancer, one of the most lethal malignancies, is increasing in incidence. While survival rates for many cancers have improved dramatically over the last 20 years, people with pancreatic cancer have persistently poor outcomes. Potential cure for pancreatic cancer involves surgical resection...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/10/2539 |
| _version_ | 1797500984137613312 |
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| author | Katherina P. Farr Daniel Moses Koroush S. Haghighi Phoebe A. Phillips Claudia M. Hillenbrand Boon H. Chua |
| author_facet | Katherina P. Farr Daniel Moses Koroush S. Haghighi Phoebe A. Phillips Claudia M. Hillenbrand Boon H. Chua |
| author_sort | Katherina P. Farr |
| collection | DOAJ |
| description | Pancreatic cancer, one of the most lethal malignancies, is increasing in incidence. While survival rates for many cancers have improved dramatically over the last 20 years, people with pancreatic cancer have persistently poor outcomes. Potential cure for pancreatic cancer involves surgical resection and adjuvant therapy. However, approximately 85% of patients diagnosed with pancreatic cancer are not suitable for potentially curative therapy due to locally advanced or metastatic disease stage. Because of this stark survival contrast, any improvement in early detection would likely significantly improve survival of patients with pancreatic cancer through earlier intervention. This comprehensive scoping review describes the current evidence on groups at high risk for developing pancreatic cancer, including individuals with inherited predisposition, pancreatic cystic lesions, diabetes, and pancreatitis. We review the current roles of imaging modalities focusing on early detection of pancreatic cancer. Additionally, we propose the use of advanced imaging modalities to identify early, potentially curable pancreatic cancer in high-risk cohorts. We discuss innovative imaging techniques for early detection of pancreatic cancer, but its widespread application requires further investigation and potentially a combination with other non-invasive biomarkers. |
| first_indexed | 2024-03-10T03:11:44Z |
| format | Article |
| id | doaj.art-8c2a11304ea64ea4a22fce5c6b01ccc9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:11:44Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8c2a11304ea64ea4a22fce5c6b01ccc92023-11-23T10:24:36ZengMDPI AGCancers2072-66942022-05-011410253910.3390/cancers14102539Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research OpportunitiesKatherina P. Farr0Daniel Moses1Koroush S. Haghighi2Phoebe A. Phillips3Claudia M. Hillenbrand4Boon H. Chua5School of Clinical Medicine, Faculty of Medicine & Health, UNSW, Sydney, NSW 2052, AustraliaGraduate School of Biomedical Engineering, UNSW, Sydney, NSW 2052, AustraliaSchool of Clinical Medicine, Faculty of Medicine & Health, UNSW, Sydney, NSW 2052, AustraliaPancreatic Cancer Translational Research Group, School of Clinical Medicine, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2052, AustraliaResearch Imaging NSW, Division of Research & Enterprise, UNSW, Sydney, NSW 2052, AustraliaSchool of Clinical Medicine, Faculty of Medicine & Health, UNSW, Sydney, NSW 2052, AustraliaPancreatic cancer, one of the most lethal malignancies, is increasing in incidence. While survival rates for many cancers have improved dramatically over the last 20 years, people with pancreatic cancer have persistently poor outcomes. Potential cure for pancreatic cancer involves surgical resection and adjuvant therapy. However, approximately 85% of patients diagnosed with pancreatic cancer are not suitable for potentially curative therapy due to locally advanced or metastatic disease stage. Because of this stark survival contrast, any improvement in early detection would likely significantly improve survival of patients with pancreatic cancer through earlier intervention. This comprehensive scoping review describes the current evidence on groups at high risk for developing pancreatic cancer, including individuals with inherited predisposition, pancreatic cystic lesions, diabetes, and pancreatitis. We review the current roles of imaging modalities focusing on early detection of pancreatic cancer. Additionally, we propose the use of advanced imaging modalities to identify early, potentially curable pancreatic cancer in high-risk cohorts. We discuss innovative imaging techniques for early detection of pancreatic cancer, but its widespread application requires further investigation and potentially a combination with other non-invasive biomarkers.https://www.mdpi.com/2072-6694/14/10/2539pancreatic cancerpancreatic ductal adenocarcinomascreeningearly detectionpancreatic cystic lesionsMRI |
| spellingShingle | Katherina P. Farr Daniel Moses Koroush S. Haghighi Phoebe A. Phillips Claudia M. Hillenbrand Boon H. Chua Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities Cancers pancreatic cancer pancreatic ductal adenocarcinoma screening early detection pancreatic cystic lesions MRI |
| title | Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities |
| title_full | Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities |
| title_fullStr | Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities |
| title_full_unstemmed | Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities |
| title_short | Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities |
| title_sort | imaging modalities for early detection of pancreatic cancer current state and future research opportunities |
| topic | pancreatic cancer pancreatic ductal adenocarcinoma screening early detection pancreatic cystic lesions MRI |
| url | https://www.mdpi.com/2072-6694/14/10/2539 |
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