Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters
Gentisic acid and epicatechin are two major compounds in phenolic acids and flavonoids of litchi-flower-water extracts (LFWEs), respectively. Increased (p < 0.05) serum lipids and liver size/lipid, damage/inflammatory indices, TBARS value, CRP level, MMP-9 activity, and decreased (p < 0.05) li...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464612001144 |
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| author | Yuan-Yen Chang Deng-Jye Yang Chih-Hsien Chiu Yi-Ling Lin Jr-Wei Chen Yi-Chen Chen |
| author_facet | Yuan-Yen Chang Deng-Jye Yang Chih-Hsien Chiu Yi-Ling Lin Jr-Wei Chen Yi-Chen Chen |
| author_sort | Yuan-Yen Chang |
| collection | DOAJ |
| description | Gentisic acid and epicatechin are two major compounds in phenolic acids and flavonoids of litchi-flower-water extracts (LFWEs), respectively. Increased (p < 0.05) serum lipids and liver size/lipid, damage/inflammatory indices, TBARS value, CRP level, MMP-9 activity, and decreased (p < 0.05) liver GSH and TEAC levels, and SOD, CAT and GSH-Px activities were observed in high-fat-diet fed hamsters compared to normal-fat-dietary hamsters. Those biochemical values of high-fat-diet fed hamsters were significant improved (p < 0.05) by drinking LFWEs. In addition, these improvements on liver damage induced by a high-fat diet were also evidenced in the histopathological examination of livers where less microvesicular steatosis and no necrotic/inflammatory cells were observed in high-fat-diet fed hamster drinking LFWEs. Therefore, protective effects of LFWEs on liver damage of high-fat-diet fed hamsters can be accounted for antioxidative properties and anti-inflammatory effects of LFWEs. |
| first_indexed | 2024-12-17T12:35:42Z |
| format | Article |
| id | doaj.art-8c2c2b0968fb49b087d6c601dce6361d |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T12:35:42Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8c2c2b0968fb49b087d6c601dce6361d2022-12-21T21:48:17ZengElsevierJournal of Functional Foods1756-46462013-01-01514452Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamstersYuan-Yen Chang0Deng-Jye Yang1Chih-Hsien Chiu2Yi-Ling Lin3Jr-Wei Chen4Yi-Chen Chen5Department of Microbiology and Immunology, School of Medicine & Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, TaiwanSchool of Health Diet and Industry Management, Chung Shan Medical University, Taichung 402, TaiwanDepartment of Animal Science and Technology, National Taiwan University, Taipei 106, TaiwanInstitute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, TaiwanLivestock Industry Division, Animal Industry Department, Council of Agriculture, Executive Yuan, TaiwanDepartment of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan; Zoonoses Research Center, National Taiwan University, Taipei 106, Taiwan; Corresponding author at: Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan. Tel.: +886 2 33664180; fax: +886 2 27324070.Gentisic acid and epicatechin are two major compounds in phenolic acids and flavonoids of litchi-flower-water extracts (LFWEs), respectively. Increased (p < 0.05) serum lipids and liver size/lipid, damage/inflammatory indices, TBARS value, CRP level, MMP-9 activity, and decreased (p < 0.05) liver GSH and TEAC levels, and SOD, CAT and GSH-Px activities were observed in high-fat-diet fed hamsters compared to normal-fat-dietary hamsters. Those biochemical values of high-fat-diet fed hamsters were significant improved (p < 0.05) by drinking LFWEs. In addition, these improvements on liver damage induced by a high-fat diet were also evidenced in the histopathological examination of livers where less microvesicular steatosis and no necrotic/inflammatory cells were observed in high-fat-diet fed hamster drinking LFWEs. Therefore, protective effects of LFWEs on liver damage of high-fat-diet fed hamsters can be accounted for antioxidative properties and anti-inflammatory effects of LFWEs.http://www.sciencedirect.com/science/article/pii/S1756464612001144Antioxidative capacityHepatic lipidsLitchi-flower-water-extractLiver cytokine levelLiver damage indexMatrix metalloproteinase |
| spellingShingle | Yuan-Yen Chang Deng-Jye Yang Chih-Hsien Chiu Yi-Ling Lin Jr-Wei Chen Yi-Chen Chen Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters Journal of Functional Foods Antioxidative capacity Hepatic lipids Litchi-flower-water-extract Liver cytokine level Liver damage index Matrix metalloproteinase |
| title | Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters |
| title_full | Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters |
| title_fullStr | Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters |
| title_full_unstemmed | Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters |
| title_short | Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters |
| title_sort | antioxidative and anti inflammatory effects of polyphenol rich litchi litchi chinensis sonn flower water extract on livers of high fat diet fed hamsters |
| topic | Antioxidative capacity Hepatic lipids Litchi-flower-water-extract Liver cytokine level Liver damage index Matrix metalloproteinase |
| url | http://www.sciencedirect.com/science/article/pii/S1756464612001144 |
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