MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification
The ideas of deep-space human exploration, interplanetary travel, and space civilizations are becoming a reality. However, numerous hindrances remain standing in the way of accomplishing these feats, one of which is space ionizing radiation. Space ionizing radiation has become the most hazardous hea...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022015559 |
| _version_ | 1818472352320585728 |
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| author | Sumeth Klomchitcharoen Tanchanok Tangwattanasirikun Sean Gallup Noparin Smerwong Peetimon Arunwiriyakit Pisitchai Tachavises Jin Tangkijngamwong Pichamon Phatthanaanukun Benjamard Jirapanyalerd Siripak Chattanupakorn Visarut Rungpongvanich Norawit Nangsue Krai Meemon Patompon Wongtrakoonkate Suradej Hongeng Yodchanan Wongsawat |
| author_facet | Sumeth Klomchitcharoen Tanchanok Tangwattanasirikun Sean Gallup Noparin Smerwong Peetimon Arunwiriyakit Pisitchai Tachavises Jin Tangkijngamwong Pichamon Phatthanaanukun Benjamard Jirapanyalerd Siripak Chattanupakorn Visarut Rungpongvanich Norawit Nangsue Krai Meemon Patompon Wongtrakoonkate Suradej Hongeng Yodchanan Wongsawat |
| author_sort | Sumeth Klomchitcharoen |
| collection | DOAJ |
| description | The ideas of deep-space human exploration, interplanetary travel, and space civilizations are becoming a reality. However, numerous hindrances remain standing in the way of accomplishing these feats, one of which is space ionizing radiation. Space ionizing radiation has become the most hazardous health risk for long-term human space exploration, as it can induce chromosomal damage and epigenetic changes. The Minerva mission aims to demonstrate cutting-edge technology to inhibit DNA damage against deep-space radiation exposure by using genetic modification. The concept of the experiment is to transform a creature with radiation intolerance into a transgenic organism that is radiation-tolerant. In this mission, Caenorhabditis elegans (C. elegans) will be genetically engineered with a protein-coding gene associated with DNA damage protection called damage suppressor (Dsup). Dsup is a nucleosome-binding protein from the tardigrade Ramazzottius varieornatus that has a unique ability to prevent DNA damage. This paper describes the feasibility of Minerva CubeSat, which will venture out to cis-lunar orbit with a biosensor payload capable of sustaining and culturing C. elegans under space environment conditions for 4 months. The mission will set in motion a paradigm shift corresponding to future space medicines and how they will be developed in the future, introducing a platform suitable for future experiments in the fields of space biology. Ultimately, the paramount objective of Minerva will be to test the limits of genetic engineering and incorporate it into the arduous journey of human perseverance to overcome the boundaries of space exploration—a vital step in making Mars colonization safe. |
| first_indexed | 2024-04-14T04:06:00Z |
| format | Article |
| id | doaj.art-8c2f53bfe8284500a19da8ce47f6175d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-14T04:06:00Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8c2f53bfe8284500a19da8ce47f6175d2022-12-22T02:13:21ZengElsevierHeliyon2405-84402022-08-0188e10267MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modificationSumeth Klomchitcharoen0Tanchanok Tangwattanasirikun1Sean Gallup2Noparin Smerwong3Peetimon Arunwiriyakit4Pisitchai Tachavises5Jin Tangkijngamwong6Pichamon Phatthanaanukun7Benjamard Jirapanyalerd8Siripak Chattanupakorn9Visarut Rungpongvanich10Norawit Nangsue11Krai Meemon12Patompon Wongtrakoonkate13Suradej Hongeng14Yodchanan Wongsawat15Brain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, ThailandInstitute of Field Robotics, King Mongkut's University of Technology Thonburi, Bangkok, ThailandDepartment of Anatomy, Faculty of Science, Mahidol University, Bangkok, ThailandDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, ThailandSection for Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandBrain-Computer Interface Laboratory, Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, Thailand; Corresponding author.The ideas of deep-space human exploration, interplanetary travel, and space civilizations are becoming a reality. However, numerous hindrances remain standing in the way of accomplishing these feats, one of which is space ionizing radiation. Space ionizing radiation has become the most hazardous health risk for long-term human space exploration, as it can induce chromosomal damage and epigenetic changes. The Minerva mission aims to demonstrate cutting-edge technology to inhibit DNA damage against deep-space radiation exposure by using genetic modification. The concept of the experiment is to transform a creature with radiation intolerance into a transgenic organism that is radiation-tolerant. In this mission, Caenorhabditis elegans (C. elegans) will be genetically engineered with a protein-coding gene associated with DNA damage protection called damage suppressor (Dsup). Dsup is a nucleosome-binding protein from the tardigrade Ramazzottius varieornatus that has a unique ability to prevent DNA damage. This paper describes the feasibility of Minerva CubeSat, which will venture out to cis-lunar orbit with a biosensor payload capable of sustaining and culturing C. elegans under space environment conditions for 4 months. The mission will set in motion a paradigm shift corresponding to future space medicines and how they will be developed in the future, introducing a platform suitable for future experiments in the fields of space biology. Ultimately, the paramount objective of Minerva will be to test the limits of genetic engineering and incorporate it into the arduous journey of human perseverance to overcome the boundaries of space exploration—a vital step in making Mars colonization safe.http://www.sciencedirect.com/science/article/pii/S2405844022015559CubeSatSpace radiationAstrobiologyGene editingTransgenics |
| spellingShingle | Sumeth Klomchitcharoen Tanchanok Tangwattanasirikun Sean Gallup Noparin Smerwong Peetimon Arunwiriyakit Pisitchai Tachavises Jin Tangkijngamwong Pichamon Phatthanaanukun Benjamard Jirapanyalerd Siripak Chattanupakorn Visarut Rungpongvanich Norawit Nangsue Krai Meemon Patompon Wongtrakoonkate Suradej Hongeng Yodchanan Wongsawat MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification Heliyon CubeSat Space radiation Astrobiology Gene editing Transgenics |
| title | MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification |
| title_full | MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification |
| title_fullStr | MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification |
| title_full_unstemmed | MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification |
| title_short | MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification |
| title_sort | minerva a cubesat for demonstrating dna damage mitigation against space radiation in c elegans by using genetic modification |
| topic | CubeSat Space radiation Astrobiology Gene editing Transgenics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022015559 |
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