Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils
Pulmonary hypertension is characterized by increased pulmonary arterial pressure, driven in part by inflammatory infiltrates. Here, the authors show that in mice, transgenic expression of mutant JAK2 leads to clonal hematopoiesis and lung accumulation of elastase- and cytokine-expressing neutrophils...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26435-0 |
| _version_ | 1818938233800622080 |
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| author | Yusuke Kimishima Tomofumi Misaka Tetsuro Yokokawa Kento Wada Koki Ueda Koichi Sugimoto Keiji Minakawa Kazuhiko Nakazato Takafumi Ishida Motohiko Oshima Shuhei Koide Kotaro Shide Kazuya Shimoda Atsushi Iwama Kazuhiko Ikeda Yasuchika Takeishi |
| author_facet | Yusuke Kimishima Tomofumi Misaka Tetsuro Yokokawa Kento Wada Koki Ueda Koichi Sugimoto Keiji Minakawa Kazuhiko Nakazato Takafumi Ishida Motohiko Oshima Shuhei Koide Kotaro Shide Kazuya Shimoda Atsushi Iwama Kazuhiko Ikeda Yasuchika Takeishi |
| author_sort | Yusuke Kimishima |
| collection | DOAJ |
| description | Pulmonary hypertension is characterized by increased pulmonary arterial pressure, driven in part by inflammatory infiltrates. Here, the authors show that in mice, transgenic expression of mutant JAK2 leads to clonal hematopoiesis and lung accumulation of elastase- and cytokine-expressing neutrophils, and that the phenotype can be reversed by ALK1 inhibition. |
| first_indexed | 2024-12-20T06:04:36Z |
| format | Article |
| id | doaj.art-8c2f8ad2f44b4473b4f42dcc6120259b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T06:04:36Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8c2f8ad2f44b4473b4f42dcc6120259b2022-12-21T19:50:51ZengNature PortfolioNature Communications2041-17232021-10-0112111810.1038/s41467-021-26435-0Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophilsYusuke Kimishima0Tomofumi Misaka1Tetsuro Yokokawa2Kento Wada3Koki Ueda4Koichi Sugimoto5Keiji Minakawa6Kazuhiko Nakazato7Takafumi Ishida8Motohiko Oshima9Shuhei Koide10Kotaro Shide11Kazuya Shimoda12Atsushi Iwama13Kazuhiko Ikeda14Yasuchika Takeishi15Department of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of TokyoDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of TokyoDepartment of Gastroenterology and Hematology, University of MiyazakiDepartment of Gastroenterology and Hematology, University of MiyazakiDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of TokyoDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityPulmonary hypertension is characterized by increased pulmonary arterial pressure, driven in part by inflammatory infiltrates. Here, the authors show that in mice, transgenic expression of mutant JAK2 leads to clonal hematopoiesis and lung accumulation of elastase- and cytokine-expressing neutrophils, and that the phenotype can be reversed by ALK1 inhibition.https://doi.org/10.1038/s41467-021-26435-0 |
| spellingShingle | Yusuke Kimishima Tomofumi Misaka Tetsuro Yokokawa Kento Wada Koki Ueda Koichi Sugimoto Keiji Minakawa Kazuhiko Nakazato Takafumi Ishida Motohiko Oshima Shuhei Koide Kotaro Shide Kazuya Shimoda Atsushi Iwama Kazuhiko Ikeda Yasuchika Takeishi Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils Nature Communications |
| title | Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils |
| title_full | Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils |
| title_fullStr | Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils |
| title_full_unstemmed | Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils |
| title_short | Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils |
| title_sort | clonal hematopoiesis with jak2v617f promotes pulmonary hypertension with alk1 upregulation in lung neutrophils |
| url | https://doi.org/10.1038/s41467-021-26435-0 |
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