Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved]
Epstein-Barr virus (EBV) is a common human herpes virus known to infect the majority of the world population. Infection with EBV is often asymptomatic but can manifest in a range of pathologies from infectious mononucleosis to severe cancers of epithelial and lymphocytic origin. Indeed, in the past...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-03-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-386/v1 |
| _version_ | 1828489811950829568 |
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| author | Brent A. Stanfield Micah A. Luftig |
| author_facet | Brent A. Stanfield Micah A. Luftig |
| author_sort | Brent A. Stanfield |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV) is a common human herpes virus known to infect the majority of the world population. Infection with EBV is often asymptomatic but can manifest in a range of pathologies from infectious mononucleosis to severe cancers of epithelial and lymphocytic origin. Indeed, in the past decade, EBV has been linked to nearly 10% of all gastric cancers. Furthermore, recent advances in high-throughput next-generation sequencing and the development of humanized mice, which effectively model EBV pathogenesis, have led to a wealth of knowledge pertaining to strain variation and host-pathogen interaction. This review highlights some recent advances in our understanding of EBV biology, focusing on new findings on the early events of infection, the role EBV plays in gastric cancer, new strain variation, and humanized mouse models of EBV infection. |
| first_indexed | 2024-12-11T10:32:34Z |
| format | Article |
| id | doaj.art-8c30a3cc13d84ad8bd6db8473b4981b0 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T10:32:34Z |
| publishDate | 2017-03-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-8c30a3cc13d84ad8bd6db8473b4981b02022-12-22T01:10:51ZengF1000 Research LtdF1000Research2046-14022017-03-01610.12688/f1000research.10591.111413Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved]Brent A. Stanfield0Micah A. Luftig1Department of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University Medical Center, Durham, NC, USADepartment of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University Medical Center, Durham, NC, USAEpstein-Barr virus (EBV) is a common human herpes virus known to infect the majority of the world population. Infection with EBV is often asymptomatic but can manifest in a range of pathologies from infectious mononucleosis to severe cancers of epithelial and lymphocytic origin. Indeed, in the past decade, EBV has been linked to nearly 10% of all gastric cancers. Furthermore, recent advances in high-throughput next-generation sequencing and the development of humanized mice, which effectively model EBV pathogenesis, have led to a wealth of knowledge pertaining to strain variation and host-pathogen interaction. This review highlights some recent advances in our understanding of EBV biology, focusing on new findings on the early events of infection, the role EBV plays in gastric cancer, new strain variation, and humanized mouse models of EBV infection.https://f1000research.com/articles/6-386/v1Animal GeneticsCellular Microbiology & PathogenesisEpidemiologyGastrointestinal CancersGenetics of the Immune SystemImmunity to InfectionsImmunopharmacology & Hematologic PharmacologyLeukocyte ActivationLeukocyte Signaling & Gene ExpressionLymphomas & MyelomasMedical MicrobiologyVirology |
| spellingShingle | Brent A. Stanfield Micah A. Luftig Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved] F1000Research Animal Genetics Cellular Microbiology & Pathogenesis Epidemiology Gastrointestinal Cancers Genetics of the Immune System Immunity to Infections Immunopharmacology & Hematologic Pharmacology Leukocyte Activation Leukocyte Signaling & Gene Expression Lymphomas & Myelomas Medical Microbiology Virology |
| title | Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved] |
| title_full | Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved] |
| title_fullStr | Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved] |
| title_full_unstemmed | Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved] |
| title_short | Recent advances in understanding Epstein-Barr virus [version 1; referees: 4 approved] |
| title_sort | recent advances in understanding epstein barr virus version 1 referees 4 approved |
| topic | Animal Genetics Cellular Microbiology & Pathogenesis Epidemiology Gastrointestinal Cancers Genetics of the Immune System Immunity to Infections Immunopharmacology & Hematologic Pharmacology Leukocyte Activation Leukocyte Signaling & Gene Expression Lymphomas & Myelomas Medical Microbiology Virology |
| url | https://f1000research.com/articles/6-386/v1 |
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