tRNA Metabolism and Lung Cancer: Beyond Translation
Lung cancer, one of the most malignant tumors, has extremely high morbidity and mortality, posing a serious threat to global health. It is an urgent need to fully understand the pathogenesis of lung cancer and provide new ideas for its treatment. Interestingly, accumulating evidence has identified t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.659388/full |
| _version_ | 1818664234288939008 |
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| author | Meng Bian Shiqiong Huang Dongsheng Yu Zheng Zhou |
| author_facet | Meng Bian Shiqiong Huang Dongsheng Yu Zheng Zhou |
| author_sort | Meng Bian |
| collection | DOAJ |
| description | Lung cancer, one of the most malignant tumors, has extremely high morbidity and mortality, posing a serious threat to global health. It is an urgent need to fully understand the pathogenesis of lung cancer and provide new ideas for its treatment. Interestingly, accumulating evidence has identified that transfer RNAs (tRNAs) and tRNA metabolism–associated enzymes not only participate in the protein translation but also play an important role in the occurrence and development of lung cancer. In this review, we summarize the different aspects of tRNA metabolism in lung cancer, such as tRNA transcription and mutation, tRNA molecules and derivatives, tRNA-modifying enzymes, and aminoacyl-tRNA synthetases (ARSs), aiming at a better understanding of the pathogenesis of lung cancer and providing new therapeutic strategies for it. |
| first_indexed | 2024-12-17T05:29:30Z |
| format | Article |
| id | doaj.art-8c3126d152de4ec29802cc3d7649112a |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-17T05:29:30Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-8c3126d152de4ec29802cc3d7649112a2022-12-21T22:01:46ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-09-01810.3389/fmolb.2021.659388659388tRNA Metabolism and Lung Cancer: Beyond TranslationMeng Bian0Shiqiong Huang1Dongsheng Yu2Zheng Zhou3Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Hospital of Changsha, Changsha, ChinaDepartment of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaLung cancer, one of the most malignant tumors, has extremely high morbidity and mortality, posing a serious threat to global health. It is an urgent need to fully understand the pathogenesis of lung cancer and provide new ideas for its treatment. Interestingly, accumulating evidence has identified that transfer RNAs (tRNAs) and tRNA metabolism–associated enzymes not only participate in the protein translation but also play an important role in the occurrence and development of lung cancer. In this review, we summarize the different aspects of tRNA metabolism in lung cancer, such as tRNA transcription and mutation, tRNA molecules and derivatives, tRNA-modifying enzymes, and aminoacyl-tRNA synthetases (ARSs), aiming at a better understanding of the pathogenesis of lung cancer and providing new therapeutic strategies for it.https://www.frontiersin.org/articles/10.3389/fmolb.2021.659388/fulllung cancerpathogenesistherapeuticstRNA derivativestRNA modificationstRNA aminoacylation |
| spellingShingle | Meng Bian Shiqiong Huang Dongsheng Yu Zheng Zhou tRNA Metabolism and Lung Cancer: Beyond Translation Frontiers in Molecular Biosciences lung cancer pathogenesis therapeutics tRNA derivatives tRNA modifications tRNA aminoacylation |
| title | tRNA Metabolism and Lung Cancer: Beyond Translation |
| title_full | tRNA Metabolism and Lung Cancer: Beyond Translation |
| title_fullStr | tRNA Metabolism and Lung Cancer: Beyond Translation |
| title_full_unstemmed | tRNA Metabolism and Lung Cancer: Beyond Translation |
| title_short | tRNA Metabolism and Lung Cancer: Beyond Translation |
| title_sort | trna metabolism and lung cancer beyond translation |
| topic | lung cancer pathogenesis therapeutics tRNA derivatives tRNA modifications tRNA aminoacylation |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.659388/full |
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