Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changes
Background: The Unani formulation Majun Brahmi (MB), a combination of herbs, is used in India as a brain tonic and memory enhancer. Aluminium deposition in the brain is associated with the development of neurodegenerative diseases. Aims and Objectives: The present study was designed to observe th...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-08-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/53990 |
| _version_ | 1797767042808414208 |
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| author | Monika Kumari Puja Kumari Jha Mahmood Ahmed Khan Amjad Saifi Vinod Kumar Arora Sumita Halder Yasmeen Shamsi Rafat Sultana Ahmed |
| author_facet | Monika Kumari Puja Kumari Jha Mahmood Ahmed Khan Amjad Saifi Vinod Kumar Arora Sumita Halder Yasmeen Shamsi Rafat Sultana Ahmed |
| author_sort | Monika Kumari |
| collection | DOAJ |
| description | Background: The Unani formulation Majun Brahmi (MB), a combination of herbs, is used in India as a brain tonic and memory enhancer. Aluminium deposition in the brain is associated with the development of neurodegenerative diseases.
Aims and Objectives: The present study was designed to observe that the effects of MB have been evaluated on aluminium trichloride
or aluminium chloride (AlCl3)-induced cognitive impairment in an experimental rat model.
Materials and Methods: Twenty male Wistar albino rats were divided into four groups of five rats each. AlCl3 was administered orally for 30 days to induce cognitive impairment. Group I received saline, Group II-AlCl3 (100 mg/kg b.wt), Group III-MB (1027.77 mg/kg b.wt), and Group IV-AlCl3 + MB (100 mg/kg b.wt+1027.77 mg/kg b.wt). At the end of the experiment, rats were subjected to behavioral and biochemical assessments.
Results: Animals treated with AlCl3 showed a significant increase in time to reach the platform in the Morris water maze test (MWM), prolonged transfer latency (TL) in the elevated plus maze, and decreased step-down latency in the passive avoidance test, as compared to controls (P<0.01). Cotreatment with MB resulted in a reduced time to reach the platform in MWM, increased step-down latencies, and decreased TL. AlCl3 induction significantly increased malondialdehyde and decreased superoxide dismutase, glutathione reductase, glutathione, total antioxidant capacity, and catalase levels. Concomitant administration of MB significantly attenuated the effects AlCl3 on lipid peroxidation and restored the reduced antioxidant parameters.
Conclusion: The study provides strong evidence for the potential use of MB in the treatment of neurodegenerative disorders like Alzheimer’s disease. |
| first_indexed | 2024-03-12T20:33:23Z |
| format | Article |
| id | doaj.art-8c31288970344c3588f4376773ead79a |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-12T20:33:23Z |
| publishDate | 2023-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-8c31288970344c3588f4376773ead79a2023-08-01T16:26:01ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-08-011484249https://doi.org/10.3126/ajms.v14i8.53990Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changesMonika Kumari 0https://orcid.org/0009-0000-3916-4588Puja Kumari Jha 1https://orcid.org/0000-0002-4662-9897Mahmood Ahmed Khan 2https://orcid.org/0000-0002-9604-2373Amjad Saifi 3https://orcid.org/0009-0004-0160-9317Vinod Kumar Arora 4https://orcid.org/0000-0003-3121-1989Sumita Halder 5https://orcid.org/0000-0001-5268-6444Yasmeen Shamsi 6https://orcid.org/0000-0001-6398-1879Rafat Sultana Ahmed 7https://orcid.org/0000-0003-3421-0236Senior Research Fellow, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India Assistant Professor, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India Research Scholar, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, IndiaSenior Research Fellow, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India Director Professor, Department of Pathology, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India Professor, Department of Pharmacology, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India Professor, Department of Moalajat, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India Director Professor, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India Background: The Unani formulation Majun Brahmi (MB), a combination of herbs, is used in India as a brain tonic and memory enhancer. Aluminium deposition in the brain is associated with the development of neurodegenerative diseases. Aims and Objectives: The present study was designed to observe that the effects of MB have been evaluated on aluminium trichloride or aluminium chloride (AlCl3)-induced cognitive impairment in an experimental rat model. Materials and Methods: Twenty male Wistar albino rats were divided into four groups of five rats each. AlCl3 was administered orally for 30 days to induce cognitive impairment. Group I received saline, Group II-AlCl3 (100 mg/kg b.wt), Group III-MB (1027.77 mg/kg b.wt), and Group IV-AlCl3 + MB (100 mg/kg b.wt+1027.77 mg/kg b.wt). At the end of the experiment, rats were subjected to behavioral and biochemical assessments. Results: Animals treated with AlCl3 showed a significant increase in time to reach the platform in the Morris water maze test (MWM), prolonged transfer latency (TL) in the elevated plus maze, and decreased step-down latency in the passive avoidance test, as compared to controls (P<0.01). Cotreatment with MB resulted in a reduced time to reach the platform in MWM, increased step-down latencies, and decreased TL. AlCl3 induction significantly increased malondialdehyde and decreased superoxide dismutase, glutathione reductase, glutathione, total antioxidant capacity, and catalase levels. Concomitant administration of MB significantly attenuated the effects AlCl3 on lipid peroxidation and restored the reduced antioxidant parameters. Conclusion: The study provides strong evidence for the potential use of MB in the treatment of neurodegenerative disorders like Alzheimer’s disease.https://www.nepjol.info/index.php/AJMS/article/view/53990cognitive impairment; morris water maze; passive avoidance test; elevated plus maze; majun brahmi; oxidative stress |
| spellingShingle | Monika Kumari Puja Kumari Jha Mahmood Ahmed Khan Amjad Saifi Vinod Kumar Arora Sumita Halder Yasmeen Shamsi Rafat Sultana Ahmed Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changes Asian Journal of Medical Sciences cognitive impairment; morris water maze; passive avoidance test; elevated plus maze; majun brahmi; oxidative stress |
| title | Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changes |
| title_full | Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changes |
| title_fullStr | Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changes |
| title_full_unstemmed | Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changes |
| title_short | Protective effects of Majun Brahmi on aluminium-induced cognitive impairment in rats: Biochemical and behavioral changes |
| title_sort | protective effects of majun brahmi on aluminium induced cognitive impairment in rats biochemical and behavioral changes |
| topic | cognitive impairment; morris water maze; passive avoidance test; elevated plus maze; majun brahmi; oxidative stress |
| url | https://www.nepjol.info/index.php/AJMS/article/view/53990 |
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