Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>)
In healthcare workers (HCWs) and in the general population, fear of adverse effects is among the main reasons behind COVID-19 vaccine hesitancy. We present data on self-reported adverse effects from a large cohort of HCWs who underwent primary (N = 470) and booster (N = 990) mRNA vaccination against...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/12/1/39 |
| _version_ | 1797339353234538496 |
|---|---|
| author | Christiaan Serbanescu-Kele Apor de Zalán Maud Bouwman Frits van Osch Jan Damoiseaux Mary-Anne Funnekotter-van der Snoek Frans Verduyn Lunel Florence Van Hunsel Janneke de Vries |
| author_facet | Christiaan Serbanescu-Kele Apor de Zalán Maud Bouwman Frits van Osch Jan Damoiseaux Mary-Anne Funnekotter-van der Snoek Frans Verduyn Lunel Florence Van Hunsel Janneke de Vries |
| author_sort | Christiaan Serbanescu-Kele Apor de Zalán |
| collection | DOAJ |
| description | In healthcare workers (HCWs) and in the general population, fear of adverse effects is among the main reasons behind COVID-19 vaccine hesitancy. We present data on self-reported adverse effects from a large cohort of HCWs who underwent primary (N = 470) and booster (N = 990) mRNA vaccination against SARS-CoV-2. We described general patterns in, and predictors of self-reported adverse effect profiles. Adverse effects following immunisation (AEFI) were reported more often after the second dose of primary immunisation than after the first dose, but there was no further increase in adverse effects following the booster round. Self-reported severity of systemic adverse effects was less following booster immunisation. Prior infection with SARS-CoV-2 was found to be a significant predictor of AEFI following primary immunisation, but was no longer a predictor after booster vaccination. Compared to other studies reporting specifically on adverse effects of SARS-CoV-2 vaccination in healthcare workers, we have a relatively large cohort size, and are the first to compare adverse effects between different rounds of vaccination. Compared to studies in the general population, we have a considerably homogenous population. Insights in AEFI following primary and booster vaccinations may help in addressing vaccine hesitancy, both in HCWs and in the general population. |
| first_indexed | 2024-03-08T09:44:47Z |
| format | Article |
| id | doaj.art-8c312d231ace4f768aa9ef5a921e44ed |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-08T09:44:47Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-8c312d231ace4f768aa9ef5a921e44ed2024-01-29T14:25:28ZengMDPI AGVaccines2076-393X2023-12-011213910.3390/vaccines12010039Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>)Christiaan Serbanescu-Kele Apor de Zalán0Maud Bouwman1Frits van Osch2Jan Damoiseaux3Mary-Anne Funnekotter-van der Snoek4Frans Verduyn Lunel5Florence Van Hunsel6Janneke de Vries7Department of Intensive Care, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Medical Microbiology, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Clinical Epidemiology, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Medical Microbiology, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Clinical Pharmacy, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Medical Microbiology, Utrecht University Medical Centre, 3584 CX Utrecht, The NetherlandsDepartment of Pharmacy, University of Groningen, 9713 AV Groningen, The NetherlandsDepartment of Medical Microbiology, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsIn healthcare workers (HCWs) and in the general population, fear of adverse effects is among the main reasons behind COVID-19 vaccine hesitancy. We present data on self-reported adverse effects from a large cohort of HCWs who underwent primary (N = 470) and booster (N = 990) mRNA vaccination against SARS-CoV-2. We described general patterns in, and predictors of self-reported adverse effect profiles. Adverse effects following immunisation (AEFI) were reported more often after the second dose of primary immunisation than after the first dose, but there was no further increase in adverse effects following the booster round. Self-reported severity of systemic adverse effects was less following booster immunisation. Prior infection with SARS-CoV-2 was found to be a significant predictor of AEFI following primary immunisation, but was no longer a predictor after booster vaccination. Compared to other studies reporting specifically on adverse effects of SARS-CoV-2 vaccination in healthcare workers, we have a relatively large cohort size, and are the first to compare adverse effects between different rounds of vaccination. Compared to studies in the general population, we have a considerably homogenous population. Insights in AEFI following primary and booster vaccinations may help in addressing vaccine hesitancy, both in HCWs and in the general population.https://www.mdpi.com/2076-393X/12/1/39COVID-19vaccineimmunisationadverse eventshealthcare workers |
| spellingShingle | Christiaan Serbanescu-Kele Apor de Zalán Maud Bouwman Frits van Osch Jan Damoiseaux Mary-Anne Funnekotter-van der Snoek Frans Verduyn Lunel Florence Van Hunsel Janneke de Vries Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>) Vaccines COVID-19 vaccine immunisation adverse events healthcare workers |
| title | Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>) |
| title_full | Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>) |
| title_fullStr | Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>) |
| title_full_unstemmed | Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>) |
| title_short | Changes in Local and Systemic Adverse Effects following Primary and Booster Immunisation against COVID-19 in an Observational Cohort of Dutch Healthcare Workers Vaccinated with BNT162b2 (Comirnaty<sup>®</sup>) |
| title_sort | changes in local and systemic adverse effects following primary and booster immunisation against covid 19 in an observational cohort of dutch healthcare workers vaccinated with bnt162b2 comirnaty sup r sup |
| topic | COVID-19 vaccine immunisation adverse events healthcare workers |
| url | https://www.mdpi.com/2076-393X/12/1/39 |
| work_keys_str_mv | AT christiaanserbanescukeleapordezalan changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup AT maudbouwman changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup AT fritsvanosch changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup AT jandamoiseaux changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup AT maryannefunnekottervandersnoek changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup AT fransverduynlunel changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup AT florencevanhunsel changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup AT jannekedevries changesinlocalandsystemicadverseeffectsfollowingprimaryandboosterimmunisationagainstcovid19inanobservationalcohortofdutchhealthcareworkersvaccinatedwithbnt162b2comirnatysupsup |