Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.

Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.

Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer's disease (AD). APP has a number of homo- and hetero-dimerizing domains, and studies have suggested that dimerization of β-secretase derived APP carboxyl terminal fragment (CTFβ, C...

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Bibliographic Details
Main Authors: Joo In Jung, Sasha Premraj, Pedro E Cruz, Thomas B Ladd, Yewon Kwak, Edward H Koo, Kevin M Felsenstein, Todd E Golde, Yong Ran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4211736?pdf=render

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