Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
The application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial barrier, and although the research emphasis has broa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/11/1/41 |
| _version_ | 1798038246672826368 |
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| author | Sam Maher David J. Brayden Luca Casettari Lisbeth Illum |
| author_facet | Sam Maher David J. Brayden Luca Casettari Lisbeth Illum |
| author_sort | Sam Maher |
| collection | DOAJ |
| description | The application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial barrier, and although the research emphasis has broadened to encompass a role for nanoparticle approaches, PEs represent a key constituent of conventional oral formulations that have progressed to clinical testing. In this review, we highlight promising PEs in early development, summarize the current state of the art, and highlight challenges to the translation of PE-based delivery systems into safe and effective oral dosage forms for patients. |
| first_indexed | 2024-04-11T21:37:37Z |
| format | Article |
| id | doaj.art-8c314de793fd4baa9eff52430ae2e3e0 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T21:37:37Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8c314de793fd4baa9eff52430ae2e3e02022-12-22T04:01:42ZengMDPI AGPharmaceutics1999-49232019-01-011114110.3390/pharmaceutics11010041pharmaceutics11010041Application of Permeation Enhancers in Oral Delivery of Macromolecules: An UpdateSam Maher0David J. Brayden1Luca Casettari2Lisbeth Illum3School of Pharmacy, Royal College of Surgeons in Ireland, St. Stephens Green, Dublin 2, IrelandSchool of Veterinary Medicine and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, IrelandDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino (PU), ItalyIDentity, 19 Cavendish Crescent North, The Park, Nottingham NG7 1BA, UKThe application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial barrier, and although the research emphasis has broadened to encompass a role for nanoparticle approaches, PEs represent a key constituent of conventional oral formulations that have progressed to clinical testing. In this review, we highlight promising PEs in early development, summarize the current state of the art, and highlight challenges to the translation of PE-based delivery systems into safe and effective oral dosage forms for patients.http://www.mdpi.com/1999-4923/11/1/41permeation enhanceroral deliveryformulationpermeabilitysafetysimulated intestinal fluidhydrophobizationepithelium |
| spellingShingle | Sam Maher David J. Brayden Luca Casettari Lisbeth Illum Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update Pharmaceutics permeation enhancer oral delivery formulation permeability safety simulated intestinal fluid hydrophobization epithelium |
| title | Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update |
| title_full | Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update |
| title_fullStr | Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update |
| title_full_unstemmed | Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update |
| title_short | Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update |
| title_sort | application of permeation enhancers in oral delivery of macromolecules an update |
| topic | permeation enhancer oral delivery formulation permeability safety simulated intestinal fluid hydrophobization epithelium |
| url | http://www.mdpi.com/1999-4923/11/1/41 |
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