Novel Perspectives in Pseudomyxoma Peritonei Treatment
Pseudomyxoma Peritonei (PMP) is an anatomo-clinical condition characterized by the implantation of neoplastic cells on peritoneal surfaces with the production of a large amount of mucin. The rarity of the disease precludes the evaluation of treatment strategies within randomized controlled trials. C...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/23/5965 |
| _version_ | 1797507995515486208 |
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| author | Antonio Sommariva Marco Tonello Giulia Rigotto Nayana Lazzari Pierluigi Pilati Maria Luisa Calabrò |
| author_facet | Antonio Sommariva Marco Tonello Giulia Rigotto Nayana Lazzari Pierluigi Pilati Maria Luisa Calabrò |
| author_sort | Antonio Sommariva |
| collection | DOAJ |
| description | Pseudomyxoma Peritonei (PMP) is an anatomo-clinical condition characterized by the implantation of neoplastic cells on peritoneal surfaces with the production of a large amount of mucin. The rarity of the disease precludes the evaluation of treatment strategies within randomized controlled trials. Cytoreductive Surgery (CRS) combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) has proven to be the only therapeutic option with potential chances of cure and long-term disease control. The present review discusses the epidemiology, pathogenesis, clinical presentation and treatment of PMP, focusing on the molecular factors involved in tumor progression and mucin production that could be used, in the upcoming future, to improve patient selection for surgery and to expand the therapeutic armamentarium. |
| first_indexed | 2024-03-10T04:56:20Z |
| format | Article |
| id | doaj.art-8c32438e3d34487c8aa323218ae354b9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:56:20Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8c32438e3d34487c8aa323218ae354b92023-11-23T02:12:17ZengMDPI AGCancers2072-66942021-11-011323596510.3390/cancers13235965Novel Perspectives in Pseudomyxoma Peritonei TreatmentAntonio Sommariva0Marco Tonello1Giulia Rigotto2Nayana Lazzari3Pierluigi Pilati4Maria Luisa Calabrò5Surgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, ItalySurgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, ItalyImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, ItalyImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, ItalySurgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, ItalyImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, ItalyPseudomyxoma Peritonei (PMP) is an anatomo-clinical condition characterized by the implantation of neoplastic cells on peritoneal surfaces with the production of a large amount of mucin. The rarity of the disease precludes the evaluation of treatment strategies within randomized controlled trials. Cytoreductive Surgery (CRS) combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) has proven to be the only therapeutic option with potential chances of cure and long-term disease control. The present review discusses the epidemiology, pathogenesis, clinical presentation and treatment of PMP, focusing on the molecular factors involved in tumor progression and mucin production that could be used, in the upcoming future, to improve patient selection for surgery and to expand the therapeutic armamentarium.https://www.mdpi.com/2072-6694/13/23/5965Pseudomyxoma Peritoneicytoreductive surgeryHIPECmucinperitoneal metastases |
| spellingShingle | Antonio Sommariva Marco Tonello Giulia Rigotto Nayana Lazzari Pierluigi Pilati Maria Luisa Calabrò Novel Perspectives in Pseudomyxoma Peritonei Treatment Cancers Pseudomyxoma Peritonei cytoreductive surgery HIPEC mucin peritoneal metastases |
| title | Novel Perspectives in Pseudomyxoma Peritonei Treatment |
| title_full | Novel Perspectives in Pseudomyxoma Peritonei Treatment |
| title_fullStr | Novel Perspectives in Pseudomyxoma Peritonei Treatment |
| title_full_unstemmed | Novel Perspectives in Pseudomyxoma Peritonei Treatment |
| title_short | Novel Perspectives in Pseudomyxoma Peritonei Treatment |
| title_sort | novel perspectives in pseudomyxoma peritonei treatment |
| topic | Pseudomyxoma Peritonei cytoreductive surgery HIPEC mucin peritoneal metastases |
| url | https://www.mdpi.com/2072-6694/13/23/5965 |
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