The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder
Gut peptide hormones are one group of secretory factors produced from gastrointestinal endocrine cells with potent functions in modulating digestive functions. In recent decades, they have been found across different brain regions, many of which are involved in autism-related social, emotional and c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00073/full |
| _version_ | 1818204945205166080 |
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| author | Xin-Rui Qi Li Zhang |
| author_facet | Xin-Rui Qi Li Zhang |
| author_sort | Xin-Rui Qi |
| collection | DOAJ |
| description | Gut peptide hormones are one group of secretory factors produced from gastrointestinal endocrine cells with potent functions in modulating digestive functions. In recent decades, they have been found across different brain regions, many of which are involved in autism-related social, emotional and cognitive deficits. Clinical studies have revealed possible correlation between those hormones and autism spectrum disorder pathogenesis. In animal models, gut peptide hormones modulate neurodevelopment, synaptic transmission and neural plasticity, explaining their behavioral relevance. This review article will summarize major findings from both clinical and basic research showing the role of gut peptide hormones in mediating autism-related neurological functions, and their potential implications in autism pathogenesis. The pharmaceutical value of gut hormones in alleviating autism-associated behavioral syndromes will be discussed to provide new insights for future drug development. |
| first_indexed | 2024-12-12T03:49:18Z |
| format | Article |
| id | doaj.art-8c347a761fc44dcba1e5f674c3636c38 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T03:49:18Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-8c347a761fc44dcba1e5f674c3636c382022-12-22T00:39:27ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-03-011410.3389/fncel.2020.00073511398The Potential Role of Gut Peptide Hormones in Autism Spectrum DisorderXin-Rui Qi0Li Zhang1Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaJoint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, ChinaGut peptide hormones are one group of secretory factors produced from gastrointestinal endocrine cells with potent functions in modulating digestive functions. In recent decades, they have been found across different brain regions, many of which are involved in autism-related social, emotional and cognitive deficits. Clinical studies have revealed possible correlation between those hormones and autism spectrum disorder pathogenesis. In animal models, gut peptide hormones modulate neurodevelopment, synaptic transmission and neural plasticity, explaining their behavioral relevance. This review article will summarize major findings from both clinical and basic research showing the role of gut peptide hormones in mediating autism-related neurological functions, and their potential implications in autism pathogenesis. The pharmaceutical value of gut hormones in alleviating autism-associated behavioral syndromes will be discussed to provide new insights for future drug development.https://www.frontiersin.org/article/10.3389/fncel.2020.00073/fullautismcholecystokininghrelingut peptide hormonepituitary adenylate cyclase activating peptidesecretin |
| spellingShingle | Xin-Rui Qi Li Zhang The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder Frontiers in Cellular Neuroscience autism cholecystokinin ghrelin gut peptide hormone pituitary adenylate cyclase activating peptide secretin |
| title | The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder |
| title_full | The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder |
| title_fullStr | The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder |
| title_full_unstemmed | The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder |
| title_short | The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder |
| title_sort | potential role of gut peptide hormones in autism spectrum disorder |
| topic | autism cholecystokinin ghrelin gut peptide hormone pituitary adenylate cyclase activating peptide secretin |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.00073/full |
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