Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
Summary: High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). P...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-11-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004218301706 |
| _version_ | 1819263121015963648 |
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| author | Tatjana Wallmann Xing-Mei Zhang Majken Wallerius Sara Bolin Anne-Laure Joly Caroline Sobocki Lina Leiss Yiwen Jiang Jonas Bergh Eric C. Holland Per Ø. Enger John Andersson Fredrik J. Swartling Hrvoje Miletic Lene Uhrbom Robert A. Harris Charlotte Rolny |
| author_facet | Tatjana Wallmann Xing-Mei Zhang Majken Wallerius Sara Bolin Anne-Laure Joly Caroline Sobocki Lina Leiss Yiwen Jiang Jonas Bergh Eric C. Holland Per Ø. Enger John Andersson Fredrik J. Swartling Hrvoje Miletic Lene Uhrbom Robert A. Harris Charlotte Rolny |
| author_sort | Tatjana Wallmann |
| collection | DOAJ |
| description | Summary: High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells that have acquired expression of PDGFRB in both mouse and human low-grade glioma and HCGs. Furthermore, M2-polarized microglia but not bone marrow (BM)-derived macrophages (BMDMs) induced PDGFRB expression in glioma cells and stimulated their migratory capacity. These findings illustrate a heterotypic cross-talk between microglia and glioma cells that may enhance the migratory and invasive capacity of the latter by inducing PDGFRB. : Pathophysiology; Molecular Mechanism of Behavior; Immunology; Cancer Subject Areas: Pathophysiology, Molecular Mechanism of Behavior, Immunology, Cancer |
| first_indexed | 2024-12-23T20:08:33Z |
| format | Article |
| id | doaj.art-8c34cad0c73543d2be8db8d7c916df08 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-23T20:08:33Z |
| publishDate | 2018-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-8c34cad0c73543d2be8db8d7c916df082022-12-21T17:32:52ZengElsevieriScience2589-00422018-11-0197183Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory CapacityTatjana Wallmann0Xing-Mei Zhang1Majken Wallerius2Sara Bolin3Anne-Laure Joly4Caroline Sobocki5Lina Leiss6Yiwen Jiang7Jonas Bergh8Eric C. Holland9Per Ø. Enger10John Andersson11Fredrik J. Swartling12Hrvoje Miletic13Lene Uhrbom14Robert A. Harris15Charlotte Rolny16Karolinska Institutet, Department of Oncology-Pathology, CCK, R8:01, 171 76 Stockholm, SwedenKarolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital at Solna, CMM, 171 76 Stockholm, SwedenKarolinska Institutet, Department of Oncology-Pathology, CCK, R8:01, 171 76 Stockholm, SwedenUppsala University, Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, 751 85 Uppsala, SwedenKarolinska Institutet, Department of Medicine, CMM, 171 76 Stockholm, SwedenKarolinska Institutet, Department of Oncology-Pathology, CCK, R8:01, 171 76 Stockholm, SwedenKarolinska Institutet, Department of Oncology-Pathology, CCK, R8:01, 171 76 Stockholm, Sweden; Neuro Clinic, Haukeland University Hospital, Bergen, Norway; Oncomatrix Research Lab, University of Bergen, Bergen, NorwayUppsala University, Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, 751 85 Uppsala, Sweden; Karolinska Institutet, Department of Medical Biochemistry and Biophysics, 17177 Stockholm, SwedenKarolinska Institutet, Department of Oncology-Pathology, CCK, R8:01, 171 76 Stockholm, Sweden; Radiumhemmet, Karolinska University Hospital, 171 76 Stockholm, SwedenDivision of Human Biology, Solid Tumor and Translational Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USAOncomatrix Research Lab, University of Bergen, Bergen, Norway; Department of Neurosurgery, Haukeland University Hospital, Bergen, NorwayKarolinska Institutet, Department of Medicine, CMM, 171 76 Stockholm, SwedenUppsala University, Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, 751 85 Uppsala, SwedenDepartment of Pathology, Haukeland University Hospital, Bergen, Norway; Department of Biomedicine, University of Bergen, Bergen, NorwayUppsala University, Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, 751 85 Uppsala, SwedenKarolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital at Solna, CMM, 171 76 Stockholm, SwedenKarolinska Institutet, Department of Oncology-Pathology, CCK, R8:01, 171 76 Stockholm, Sweden; Corresponding authorSummary: High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells that have acquired expression of PDGFRB in both mouse and human low-grade glioma and HCGs. Furthermore, M2-polarized microglia but not bone marrow (BM)-derived macrophages (BMDMs) induced PDGFRB expression in glioma cells and stimulated their migratory capacity. These findings illustrate a heterotypic cross-talk between microglia and glioma cells that may enhance the migratory and invasive capacity of the latter by inducing PDGFRB. : Pathophysiology; Molecular Mechanism of Behavior; Immunology; Cancer Subject Areas: Pathophysiology, Molecular Mechanism of Behavior, Immunology, Cancerhttp://www.sciencedirect.com/science/article/pii/S2589004218301706 |
| spellingShingle | Tatjana Wallmann Xing-Mei Zhang Majken Wallerius Sara Bolin Anne-Laure Joly Caroline Sobocki Lina Leiss Yiwen Jiang Jonas Bergh Eric C. Holland Per Ø. Enger John Andersson Fredrik J. Swartling Hrvoje Miletic Lene Uhrbom Robert A. Harris Charlotte Rolny Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity iScience |
| title | Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity |
| title_full | Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity |
| title_fullStr | Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity |
| title_full_unstemmed | Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity |
| title_short | Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity |
| title_sort | microglia induce pdgfrb expression in glioma cells to enhance their migratory capacity |
| url | http://www.sciencedirect.com/science/article/pii/S2589004218301706 |
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