Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation
The safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten days...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Biotechnology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X20308298 |
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| author | Isaiane Medeiros Grazielle Louise Ribeiro de Oliveira Jaluza Luana Carvalho de Queiroz Camila de Carvalho Gomes Fabiana Maria Coimbra de Carvalho Maíra Conceição Jerônimo de Souza Lima Alexandre Coelho Serquiz Pedro Paulo de Andrade Santos Christina da Silva Camillo Bruna Leal Lima Maciel Ana Heloneida de Araújo Morais Thaís Souza Passos |
| author_facet | Isaiane Medeiros Grazielle Louise Ribeiro de Oliveira Jaluza Luana Carvalho de Queiroz Camila de Carvalho Gomes Fabiana Maria Coimbra de Carvalho Maíra Conceição Jerônimo de Souza Lima Alexandre Coelho Serquiz Pedro Paulo de Andrade Santos Christina da Silva Camillo Bruna Leal Lima Maciel Ana Heloneida de Araújo Morais Thaís Souza Passos |
| author_sort | Isaiane Medeiros |
| collection | DOAJ |
| description | The safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten days with 1) HGLI diet, 2) standard diet, 3) HGLI diet + crude carotenoid extract (CE) (12.5 mg/kg), and 4) HGLI diet + EPG (50 mg/kg). General toxicity signals were investigated, considering body weight, food intake, hematological, biochemical parameters, relative weight, morphology, and histopathology of organs. The biochemical parameters indicated the low toxicity of EPG. Acute hepatitis was observed in animals' livers, but CE and EPG groups presented improved tissue appearance. Chronic enteritis was observed in animals, with villi and intestinal glands preservation in the EPG group. The results suggest the safety and the bioactive effect of EPG, possibly related to its anti-inflammatory potential. |
| first_indexed | 2024-12-17T00:31:36Z |
| format | Article |
| id | doaj.art-8c372d5fe3a343fa8fbca9fad041645d |
| institution | Directory Open Access Journal |
| issn | 2215-017X |
| language | English |
| last_indexed | 2024-12-17T00:31:36Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj.art-8c372d5fe3a343fa8fbca9fad041645d2022-12-21T22:10:16ZengElsevierBiotechnology Reports2215-017X2020-12-0128e00567Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammationIsaiane Medeiros0Grazielle Louise Ribeiro de Oliveira1Jaluza Luana Carvalho de Queiroz2Camila de Carvalho Gomes3Fabiana Maria Coimbra de Carvalho4Maíra Conceição Jerônimo de Souza Lima5Alexandre Coelho Serquiz6Pedro Paulo de Andrade Santos7Christina da Silva Camillo8Bruna Leal Lima Maciel9Ana Heloneida de Araújo Morais10Thaís Souza Passos11Postgraduate Program in Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Biochemistry, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Biochemistry, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Biochemistry, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Brazil; Nutrition Course, Potiguar University, Natal, BrazilVeterinary Medicine Course, Potiguar University, Natal, BrazilNutrition Course, University Center of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Structural and Functional Biology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Brazil; Department of Morphology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Structural and Functional Biology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Brazil; Department of Morphology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil; Department of Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, BrazilPostgraduate Program in Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil; Corresponding author at: Department of Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, RN, 59078-970, Brazil.Department of Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, BrazilThe safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten days with 1) HGLI diet, 2) standard diet, 3) HGLI diet + crude carotenoid extract (CE) (12.5 mg/kg), and 4) HGLI diet + EPG (50 mg/kg). General toxicity signals were investigated, considering body weight, food intake, hematological, biochemical parameters, relative weight, morphology, and histopathology of organs. The biochemical parameters indicated the low toxicity of EPG. Acute hepatitis was observed in animals' livers, but CE and EPG groups presented improved tissue appearance. Chronic enteritis was observed in animals, with villi and intestinal glands preservation in the EPG group. The results suggest the safety and the bioactive effect of EPG, possibly related to its anti-inflammatory potential.http://www.sciencedirect.com/science/article/pii/S2215017X20308298β-caroteneCurcubitaceaeNanotechnologyToxicityObesity |
| spellingShingle | Isaiane Medeiros Grazielle Louise Ribeiro de Oliveira Jaluza Luana Carvalho de Queiroz Camila de Carvalho Gomes Fabiana Maria Coimbra de Carvalho Maíra Conceição Jerônimo de Souza Lima Alexandre Coelho Serquiz Pedro Paulo de Andrade Santos Christina da Silva Camillo Bruna Leal Lima Maciel Ana Heloneida de Araújo Morais Thaís Souza Passos Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation Biotechnology Reports β-carotene Curcubitaceae Nanotechnology Toxicity Obesity |
| title | Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation |
| title_full | Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation |
| title_fullStr | Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation |
| title_full_unstemmed | Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation |
| title_short | Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation |
| title_sort | safety and bioactive potential of nanoparticles containing cantaloupe melon cucumis melo l carotenoids in an experimental model of chronic inflammation |
| topic | β-carotene Curcubitaceae Nanotechnology Toxicity Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X20308298 |
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