Omicron subvariants illustrate reduced respiratory tissue penetration, cell damage and inflammatory responses in human airway epithelia

Omicron subvariants illustrate reduced respiratory tissue penetration, cell damage and inflammatory responses in human airway epithelia

IntroductionTo explore whether the reported lower pathogenicity in infected individuals of variant of concern (VoC) Omicron and its current subvariants compared to VoC Delta may be related to fundamental differences in the initial virus-tissue interaction, we assessed their ability to penetrate, rep...

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Bibliographic Details
Main Authors: Viktoria Zaderer, Hussam Abd El Halim, Anna-Lena Wyremblewsky, Gaia Lupoli, Christopher Dächert, Maximilian Muenchhoff, Alexander Graf, Helmut Blum, Cornelia Lass-Flörl, Oliver T. Keppler, Lukas A. Huber, Wilfried Posch, Doris Wilflingseder
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
VOCs
delta
omicron
epithelial barrier model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1258268/full

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