The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis
Introduction: Sarcopenia is associated with worsened outcomes in solid cancers. Temporalis muscle thickness (TMT) has emerged as a measure of sarcopenia. Hence, this study aims to evaluate the relationship between TMT and outcome measures in patients with malignant intra-axial neoplasms. Method: We...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | World Neurosurgery: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139724000498 |
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| author | Olatomiwa Olukoya Temidayo Osunronbi Damilola A. Jesuyajolu Blossom C. Uwaga Ayomide Vaughan Oluwabusayo Aluko Temitayo O. Ayantayo Jeremiah O.I. Daniel Samuel O. David Habiblah A. Jagunmolu Alieu Kanu Ayomide T. Kayode Tobi N. Olajide Lewis Thorne |
| author_facet | Olatomiwa Olukoya Temidayo Osunronbi Damilola A. Jesuyajolu Blossom C. Uwaga Ayomide Vaughan Oluwabusayo Aluko Temitayo O. Ayantayo Jeremiah O.I. Daniel Samuel O. David Habiblah A. Jagunmolu Alieu Kanu Ayomide T. Kayode Tobi N. Olajide Lewis Thorne |
| author_sort | Olatomiwa Olukoya |
| collection | DOAJ |
| description | Introduction: Sarcopenia is associated with worsened outcomes in solid cancers. Temporalis muscle thickness (TMT) has emerged as a measure of sarcopenia. Hence, this study aims to evaluate the relationship between TMT and outcome measures in patients with malignant intra-axial neoplasms. Method: We searched Medline, Embase, Scopus and Cochrane databases for relevant studies. Event ratios with 95% confidence intervals (CI) were analysed using the RevMan 5.4 software. Where meta-analysis was impossible, vote counting was used to determine the effect of TMT on outcomes. The GRADE framework was used to determine the certainty of the evidence. Results: Four outcomes were reported for three conditions across 17 studies involving 4430 patients. Glioblastoma: thicker TMT was protective for overall survival (OS) (HR 0.59; 95% CI 0.46–0.76) (GRADE low), progression free survival (PFS) (HR 0.40; 95% CI 0.26–0.62) (GRADE high), and early discontinuation of treatment (OR 0.408; 95% CI 0.168–0.989) (GRADE high); no association with complications (HR 0.82; 95% CI 0.60–1.10) (GRADE low). Brain Metastases: thicker TMT was protective for OS (HR 0.73; 95% CI 0.67–0.78) (GRADE moderate); no association with PFS (GRADE low). Primary CNS Lymphoma: TMT was protective for overall survival (HR 0.34; 95% CI 0.19–0.60) (GRADE moderate) and progression free survival (HR 0.23; 95% CI 0.09–0.56) (GRADE high). Conclusion: TMT has significant prognostic potential in intra-axial malignant neoplasms, showing a moderate to high certainty for its association with outcomes following GRADE evaluation. This will enable shared decision making between patients and clinicians. |
| first_indexed | 2024-03-07T16:22:47Z |
| format | Article |
| id | doaj.art-8c399b00728e44eeb7ee80d903ebb161 |
| institution | Directory Open Access Journal |
| issn | 2590-1397 |
| language | English |
| last_indexed | 2024-03-07T16:22:47Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj.art-8c399b00728e44eeb7ee80d903ebb1612024-03-04T04:12:19ZengElsevierWorld Neurosurgery: X2590-13972024-04-0122100318The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysisOlatomiwa Olukoya0Temidayo Osunronbi1Damilola A. Jesuyajolu2Blossom C. Uwaga3Ayomide Vaughan4Oluwabusayo Aluko5Temitayo O. Ayantayo6Jeremiah O.I. Daniel7Samuel O. David8Habiblah A. Jagunmolu9Alieu Kanu10Ayomide T. Kayode11Tobi N. Olajide12Lewis Thorne13Neurosurgery Department, Surgery Interest Group of Africa, Lagos, Nigeria; The National Hospital for Neurology and Neurosurgery, London, United Kingdom; Corresponding author. Neurosurgery department, Surgery Interest Group of Africa, Lagos, Nigeria.Neurosurgery Department, Surgery Interest Group of Africa, Lagos, Nigeria; Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaNeurosurgery Department, Surgery Interest Group of Africa, Lagos, NigeriaThe National Hospital for Neurology and Neurosurgery, London, United KingdomIntroduction: Sarcopenia is associated with worsened outcomes in solid cancers. Temporalis muscle thickness (TMT) has emerged as a measure of sarcopenia. Hence, this study aims to evaluate the relationship between TMT and outcome measures in patients with malignant intra-axial neoplasms. Method: We searched Medline, Embase, Scopus and Cochrane databases for relevant studies. Event ratios with 95% confidence intervals (CI) were analysed using the RevMan 5.4 software. Where meta-analysis was impossible, vote counting was used to determine the effect of TMT on outcomes. The GRADE framework was used to determine the certainty of the evidence. Results: Four outcomes were reported for three conditions across 17 studies involving 4430 patients. Glioblastoma: thicker TMT was protective for overall survival (OS) (HR 0.59; 95% CI 0.46–0.76) (GRADE low), progression free survival (PFS) (HR 0.40; 95% CI 0.26–0.62) (GRADE high), and early discontinuation of treatment (OR 0.408; 95% CI 0.168–0.989) (GRADE high); no association with complications (HR 0.82; 95% CI 0.60–1.10) (GRADE low). Brain Metastases: thicker TMT was protective for OS (HR 0.73; 95% CI 0.67–0.78) (GRADE moderate); no association with PFS (GRADE low). Primary CNS Lymphoma: TMT was protective for overall survival (HR 0.34; 95% CI 0.19–0.60) (GRADE moderate) and progression free survival (HR 0.23; 95% CI 0.09–0.56) (GRADE high). Conclusion: TMT has significant prognostic potential in intra-axial malignant neoplasms, showing a moderate to high certainty for its association with outcomes following GRADE evaluation. This will enable shared decision making between patients and clinicians.http://www.sciencedirect.com/science/article/pii/S2590139724000498Brain metastasesGlioblastoma (GBM)Primary CNS lymphomaPrognosisSarcopeniaTemporalis muscle thickness (TMT) |
| spellingShingle | Olatomiwa Olukoya Temidayo Osunronbi Damilola A. Jesuyajolu Blossom C. Uwaga Ayomide Vaughan Oluwabusayo Aluko Temitayo O. Ayantayo Jeremiah O.I. Daniel Samuel O. David Habiblah A. Jagunmolu Alieu Kanu Ayomide T. Kayode Tobi N. Olajide Lewis Thorne The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis World Neurosurgery: X Brain metastases Glioblastoma (GBM) Primary CNS lymphoma Prognosis Sarcopenia Temporalis muscle thickness (TMT) |
| title | The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis |
| title_full | The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis |
| title_fullStr | The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis |
| title_full_unstemmed | The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis |
| title_short | The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis |
| title_sort | prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra axial malignant brain tumours a systematic review and meta analysis |
| topic | Brain metastases Glioblastoma (GBM) Primary CNS lymphoma Prognosis Sarcopenia Temporalis muscle thickness (TMT) |
| url | http://www.sciencedirect.com/science/article/pii/S2590139724000498 |
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