The Role of Non-Coding RNA in Congenital Heart Diseases
Cardiovascular development is a complex developmental process starting with the formation of an early straight heart tube, followed by a rightward looping and the configuration of atrial and ventricular chambers. The subsequent step allows the separation of these cardiac chambers leading to the form...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/6/2/15 |
| _version_ | 1818174000275128320 |
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| author | Angel Dueñas Almudena Expósito Amelia Aranega Diego Franco |
| author_facet | Angel Dueñas Almudena Expósito Amelia Aranega Diego Franco |
| author_sort | Angel Dueñas |
| collection | DOAJ |
| description | Cardiovascular development is a complex developmental process starting with the formation of an early straight heart tube, followed by a rightward looping and the configuration of atrial and ventricular chambers. The subsequent step allows the separation of these cardiac chambers leading to the formation of a four-chambered organ. Impairment in any of these developmental processes invariably leads to cardiac defects. Importantly, our understanding of the developmental defects causing cardiac congenital heart diseases has largely increased over the last decades. The advent of the molecular era allowed to bridge morphogenetic with genetic defects and therefore our current understanding of the transcriptional regulation of cardiac morphogenesis has enormously increased. Moreover, the impact of environmental agents to genetic cascades has been demonstrated as well as of novel genomic mechanisms modulating gene regulation such as post-transcriptional regulatory mechanisms. Among post-transcriptional regulatory mechanisms, non-coding RNAs, including therein microRNAs and lncRNAs, are emerging to play pivotal roles. In this review, we summarize current knowledge on the functional role of non-coding RNAs in distinct congenital heart diseases, with particular emphasis on microRNAs and long non-coding RNAs. |
| first_indexed | 2024-12-11T19:37:26Z |
| format | Article |
| id | doaj.art-8c3ab16198274d0d9569634e82ca72b6 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-12-11T19:37:26Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-8c3ab16198274d0d9569634e82ca72b62022-12-22T00:53:07ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252019-04-01621510.3390/jcdd6020015jcdd6020015The Role of Non-Coding RNA in Congenital Heart DiseasesAngel Dueñas0Almudena Expósito1Amelia Aranega2Diego Franco3Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainCardiovascular development is a complex developmental process starting with the formation of an early straight heart tube, followed by a rightward looping and the configuration of atrial and ventricular chambers. The subsequent step allows the separation of these cardiac chambers leading to the formation of a four-chambered organ. Impairment in any of these developmental processes invariably leads to cardiac defects. Importantly, our understanding of the developmental defects causing cardiac congenital heart diseases has largely increased over the last decades. The advent of the molecular era allowed to bridge morphogenetic with genetic defects and therefore our current understanding of the transcriptional regulation of cardiac morphogenesis has enormously increased. Moreover, the impact of environmental agents to genetic cascades has been demonstrated as well as of novel genomic mechanisms modulating gene regulation such as post-transcriptional regulatory mechanisms. Among post-transcriptional regulatory mechanisms, non-coding RNAs, including therein microRNAs and lncRNAs, are emerging to play pivotal roles. In this review, we summarize current knowledge on the functional role of non-coding RNAs in distinct congenital heart diseases, with particular emphasis on microRNAs and long non-coding RNAs.https://www.mdpi.com/2308-3425/6/2/15non-coding RNAmicroRNAslncRNAscongenital heart disease |
| spellingShingle | Angel Dueñas Almudena Expósito Amelia Aranega Diego Franco The Role of Non-Coding RNA in Congenital Heart Diseases Journal of Cardiovascular Development and Disease non-coding RNA microRNAs lncRNAs congenital heart disease |
| title | The Role of Non-Coding RNA in Congenital Heart Diseases |
| title_full | The Role of Non-Coding RNA in Congenital Heart Diseases |
| title_fullStr | The Role of Non-Coding RNA in Congenital Heart Diseases |
| title_full_unstemmed | The Role of Non-Coding RNA in Congenital Heart Diseases |
| title_short | The Role of Non-Coding RNA in Congenital Heart Diseases |
| title_sort | role of non coding rna in congenital heart diseases |
| topic | non-coding RNA microRNAs lncRNAs congenital heart disease |
| url | https://www.mdpi.com/2308-3425/6/2/15 |
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