Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections
A general intravenous anesthetic propofol (2,6-diisopropylphenol) is widely used in clinical, veterinary practice and animal experiments. It activates gamma- aminobutyric acid (GABAa) receptors. Though the cerebral cortex is one of the major targets of propofol action, no study of dose dependency of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123022972 |
| _version_ | 1797320901430083584 |
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| author | Svetlana I. Shumikhina Sergei A. Kozhukhov Igor V. Bondar |
| author_facet | Svetlana I. Shumikhina Sergei A. Kozhukhov Igor V. Bondar |
| author_sort | Svetlana I. Shumikhina |
| collection | DOAJ |
| description | A general intravenous anesthetic propofol (2,6-diisopropylphenol) is widely used in clinical, veterinary practice and animal experiments. It activates gamma- aminobutyric acid (GABAa) receptors. Though the cerebral cortex is one of the major targets of propofol action, no study of dose dependency of propofol action on cat visual cortex was performed yet. Also, no such investigation was done until now using intrinsic signal optical imaging. Here, we report for the first time on the dependency of optical signal in the visual cortex (area 17/area 18) on the propofol dose. Optical imaging of intrinsic responses to visual stimuli was performed in cats before and after propofol bolus injections at different doses on the background of continuous propofol infusion. Orientation amplitude maps were recorded. We found that amplitude of optical signal significantly decreased after a bolus dose of propofol. The effect was dose- and time-dependent producing stronger suppression of optical signal under the highest bolus propofol doses and short time interval after injection. In each hemisphere, amplitude at cardinal and oblique orientations decreased almost equally. However, surprisingly, amplitude at cardinal orientations in the ipsilateral hemisphere was depressed stronger than in contralateral cortex at most time intervals. As the magnitude of optical signal represents the strength of orientation tuned component, these our data give new insights on the mechanisms of generation of orientation selectivity. Our results also provide new data toward understanding brain dynamics under anesthesia and suggest a recommendation for conducting intrinsic signal optical imaging experiments on cortical functioning under propofol anesthesia. |
| first_indexed | 2024-03-08T04:49:45Z |
| format | Article |
| id | doaj.art-8c3bf6bd555f48fa80f4124344338c1d |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T04:49:45Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-8c3bf6bd555f48fa80f4124344338c1d2024-02-08T05:18:29ZengElsevierIBRO Neuroscience Reports2667-24212024-06-0116224240Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injectionsSvetlana I. Shumikhina0Sergei A. Kozhukhov1Igor V. Bondar2Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerova Street, 117485 Moscow, Russian Federation; Corresponding author.Physiology of Sensory Systems, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerova Street, 117485 Moscow, Russian FederationPhysiology of Sensory Systems, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerova Street, 117485 Moscow, Russian FederationA general intravenous anesthetic propofol (2,6-diisopropylphenol) is widely used in clinical, veterinary practice and animal experiments. It activates gamma- aminobutyric acid (GABAa) receptors. Though the cerebral cortex is one of the major targets of propofol action, no study of dose dependency of propofol action on cat visual cortex was performed yet. Also, no such investigation was done until now using intrinsic signal optical imaging. Here, we report for the first time on the dependency of optical signal in the visual cortex (area 17/area 18) on the propofol dose. Optical imaging of intrinsic responses to visual stimuli was performed in cats before and after propofol bolus injections at different doses on the background of continuous propofol infusion. Orientation amplitude maps were recorded. We found that amplitude of optical signal significantly decreased after a bolus dose of propofol. The effect was dose- and time-dependent producing stronger suppression of optical signal under the highest bolus propofol doses and short time interval after injection. In each hemisphere, amplitude at cardinal and oblique orientations decreased almost equally. However, surprisingly, amplitude at cardinal orientations in the ipsilateral hemisphere was depressed stronger than in contralateral cortex at most time intervals. As the magnitude of optical signal represents the strength of orientation tuned component, these our data give new insights on the mechanisms of generation of orientation selectivity. Our results also provide new data toward understanding brain dynamics under anesthesia and suggest a recommendation for conducting intrinsic signal optical imaging experiments on cortical functioning under propofol anesthesia.http://www.sciencedirect.com/science/article/pii/S2667242123022972Intrinsic optical imagingOrientation selectivityPlasticityAnesthesiaPropofol |
| spellingShingle | Svetlana I. Shumikhina Sergei A. Kozhukhov Igor V. Bondar Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections IBRO Neuroscience Reports Intrinsic optical imaging Orientation selectivity Plasticity Anesthesia Propofol |
| title | Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections |
| title_full | Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections |
| title_fullStr | Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections |
| title_full_unstemmed | Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections |
| title_short | Dose-dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections |
| title_sort | dose dependent changes in orientation amplitude maps in the cat visual cortex after propofol bolus injections |
| topic | Intrinsic optical imaging Orientation selectivity Plasticity Anesthesia Propofol |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123022972 |
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