Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer.
<h4>Objective</h4>To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer.<h4>Methods</h4>Eleven male patients (me...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092211&type=printable |
| _version_ | 1826799285969092608 |
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| author | Robert M Kwee Alexander K Dik Meindert N Sosef Ralph C M Berendsen Sander Sassen Guido Lammering Ruud Clarijs Liekele E Oostenbrug Rachel L G M Blom Roy F A Vliegen |
| author_facet | Robert M Kwee Alexander K Dik Meindert N Sosef Ralph C M Berendsen Sander Sassen Guido Lammering Ruud Clarijs Liekele E Oostenbrug Rachel L G M Blom Roy F A Vliegen |
| author_sort | Robert M Kwee |
| collection | DOAJ |
| description | <h4>Objective</h4>To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer.<h4>Methods</h4>Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed.<h4>Results</h4>Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P<0.001).<h4>Conclusion</h4>Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma. |
| first_indexed | 2024-12-19T04:22:33Z |
| format | Article |
| id | doaj.art-8c3c9402e87c429dbe04d29d32a22fac |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-17T00:32:40Z |
| publishDate | 2014-01-01 |
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| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8c3c9402e87c429dbe04d29d32a22fac2025-02-21T05:34:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9221110.1371/journal.pone.0092211Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer.Robert M KweeAlexander K DikMeindert N SosefRalph C M BerendsenSander SassenGuido LammeringRuud ClarijsLiekele E OostenbrugRachel L G M BlomRoy F A Vliegen<h4>Objective</h4>To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer.<h4>Methods</h4>Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed.<h4>Results</h4>Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P<0.001).<h4>Conclusion</h4>Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092211&type=printable |
| spellingShingle | Robert M Kwee Alexander K Dik Meindert N Sosef Ralph C M Berendsen Sander Sassen Guido Lammering Ruud Clarijs Liekele E Oostenbrug Rachel L G M Blom Roy F A Vliegen Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer. PLoS ONE |
| title | Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer. |
| title_full | Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer. |
| title_fullStr | Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer. |
| title_full_unstemmed | Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer. |
| title_short | Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer. |
| title_sort | interobserver reproducibility of diffusion weighted mri in monitoring tumor response to neoadjuvant therapy in esophageal cancer |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092211&type=printable |
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