IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy
We aimed to analyze the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12p70) in colorectal cancer and evaluate the predictive significance of clinical efficacy of patients with colorectal cancer treated with anti-vascular therapy combined with chemotherapy. A...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.997665/full |
| _version_ | 1811204319921307648 |
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| author | Jingxian Zheng Jingxian Zheng Jingxian Zheng Xiaojie Wang Xiaojie Wang Xiaojie Wang Jiami Yu Jiami Yu Jiami Yu Zhouwei Zhan Zhouwei Zhan Zhouwei Zhan Zengqing Guo Zengqing Guo Zengqing Guo |
| author_facet | Jingxian Zheng Jingxian Zheng Jingxian Zheng Xiaojie Wang Xiaojie Wang Xiaojie Wang Jiami Yu Jiami Yu Jiami Yu Zhouwei Zhan Zhouwei Zhan Zhouwei Zhan Zengqing Guo Zengqing Guo Zengqing Guo |
| author_sort | Jingxian Zheng |
| collection | DOAJ |
| description | We aimed to analyze the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12p70) in colorectal cancer and evaluate the predictive significance of clinical efficacy of patients with colorectal cancer treated with anti-vascular therapy combined with chemotherapy. A retrospective study of 162 patients with colorectal cancer in Fujian Medical University Hospital was conducted from January 2019 to December 2020. A comparative analysis of the levels of IL-6, TNF-α and IL-12p70 between the two groups were studied. The relationship between the levels and the clinical characteristics of patients was observed; the factors affecting the levels of IL-6, TNF-α, and IL-12p70 in colorectal cancer patients were analyzed, and the predictive validity of the efficacy of anti-vascular therapy was evaluated. We observed that the individual expression levels of IL-6, TNF-α and IL-12p70 in the patients with colorectal cancer are related to lymph node metastasis, TNM staging, and degree of differentiation (P<0.05); however, they are irrelevant to the age, sex, and tumor location of patients with colorectal cancer (P>0.05). The multiple stepwise regression analysis indicates that lymph node metastasis and TNM staging are independent risk factors that correlate with IL-6 and IL-12p70 levels in colorectal cancer patients (P<0.01). The degree of differentiation was found to be an independent risk factor connected to TNF- α levels of patients with colorectal cancer. The change of IL-12p70 level could predict the validity of anti-vascular treatment for advanced colorectal cancer. When evaluated for combined expression, IL-6 and IL-12p70 in patients with colorectal cancer closely related to lymph node metastasis and TNM staging. IL-12p70 can be used as a predictor of anti-vascular therapy with colorectal cancer. |
| first_indexed | 2024-04-12T03:11:03Z |
| format | Article |
| id | doaj.art-8c3ce9589c5e4f65acb530566f685174 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T03:11:03Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8c3ce9589c5e4f65acb530566f6851742022-12-22T03:50:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.997665997665IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapyJingxian Zheng0Jingxian Zheng1Jingxian Zheng2Xiaojie Wang3Xiaojie Wang4Xiaojie Wang5Jiami Yu6Jiami Yu7Jiami Yu8Zhouwei Zhan9Zhouwei Zhan10Zhouwei Zhan11Zengqing Guo12Zengqing Guo13Zengqing Guo14Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, ChinaFujian Key Laboratory of Translational Cancer Medicine, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaFujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, ChinaFujian Key Laboratory of Translational Cancer Medicine, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaFujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, ChinaFujian Key Laboratory of Translational Cancer Medicine, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaFujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, ChinaFujian Key Laboratory of Translational Cancer Medicine, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaFujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, ChinaFujian Key Laboratory of Translational Cancer Medicine, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaFujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, The Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, ChinaWe aimed to analyze the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12p70) in colorectal cancer and evaluate the predictive significance of clinical efficacy of patients with colorectal cancer treated with anti-vascular therapy combined with chemotherapy. A retrospective study of 162 patients with colorectal cancer in Fujian Medical University Hospital was conducted from January 2019 to December 2020. A comparative analysis of the levels of IL-6, TNF-α and IL-12p70 between the two groups were studied. The relationship between the levels and the clinical characteristics of patients was observed; the factors affecting the levels of IL-6, TNF-α, and IL-12p70 in colorectal cancer patients were analyzed, and the predictive validity of the efficacy of anti-vascular therapy was evaluated. We observed that the individual expression levels of IL-6, TNF-α and IL-12p70 in the patients with colorectal cancer are related to lymph node metastasis, TNM staging, and degree of differentiation (P<0.05); however, they are irrelevant to the age, sex, and tumor location of patients with colorectal cancer (P>0.05). The multiple stepwise regression analysis indicates that lymph node metastasis and TNM staging are independent risk factors that correlate with IL-6 and IL-12p70 levels in colorectal cancer patients (P<0.01). The degree of differentiation was found to be an independent risk factor connected to TNF- α levels of patients with colorectal cancer. The change of IL-12p70 level could predict the validity of anti-vascular treatment for advanced colorectal cancer. When evaluated for combined expression, IL-6 and IL-12p70 in patients with colorectal cancer closely related to lymph node metastasis and TNM staging. IL-12p70 can be used as a predictor of anti-vascular therapy with colorectal cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.997665/fullIL-6colorectal cancertumor necrosis factor-alphail-12anti-vascular therapy |
| spellingShingle | Jingxian Zheng Jingxian Zheng Jingxian Zheng Xiaojie Wang Xiaojie Wang Xiaojie Wang Jiami Yu Jiami Yu Jiami Yu Zhouwei Zhan Zhouwei Zhan Zhouwei Zhan Zengqing Guo Zengqing Guo Zengqing Guo IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy Frontiers in Oncology IL-6 colorectal cancer tumor necrosis factor-alpha il-12 anti-vascular therapy |
| title | IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy |
| title_full | IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy |
| title_fullStr | IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy |
| title_full_unstemmed | IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy |
| title_short | IL-6, TNF-α and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy |
| title_sort | il 6 tnf α and il 12p70 levels in patients with colorectal cancer and their predictive value in anti vascular therapy |
| topic | IL-6 colorectal cancer tumor necrosis factor-alpha il-12 anti-vascular therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.997665/full |
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