Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms

Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms

ABSTRACT Ideal antiviral vaccines elicit antibodies (Abs) with broad strain recognition that bind to regions that are difficult to mutate for escape. Using 10 murine norovirus (MNV) strains and 5 human norovirus (HuNoV) virus-like particles (VLPs), we identified monoclonal antibody (MAb) 2D3, which...

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Bibliographic Details
Main Authors: Abimbola O. Kolawole, Hong Q. Smith, Sophia A. Svoboda, Madeline S. Lewis, Michael B. Sherman, Gillian C. Lynch, B. Montgomery Pettitt, Thomas J. Smith, Christiane E. Wobus
Format: Article
Language:English
Published: American Society for Microbiology 2017-10-01
Series:mSphere
Subjects:
antibody
neutralization
noroviruses
protein structure-function
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00334-17

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