Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases
Background: Choriocarcinoma is a curable malignant neoplasm when chemotherapy is properly implemented. However, when chemotherapy resistance occurs, disease can be fatal. Misdiagnosis is common, which may lead to delaying of the first cycle of chemotherapy and increase the possibility of chemoresist...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-07-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/49/8/10.31083/j.ceog4908179 |
| _version_ | 1811188523761401856 |
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| author | Lin-Jing Yuan Yu-Ying Chen Cai-Xia Zhu Yi-Zi Wang Guo-Fen Yang |
| author_facet | Lin-Jing Yuan Yu-Ying Chen Cai-Xia Zhu Yi-Zi Wang Guo-Fen Yang |
| author_sort | Lin-Jing Yuan |
| collection | DOAJ |
| description | Background: Choriocarcinoma is a curable malignant neoplasm when chemotherapy is properly implemented. However, when chemotherapy resistance occurs, disease can be fatal. Misdiagnosis is common, which may lead to delaying of the first cycle of chemotherapy and increase the possibility of chemoresistance. Methods: We analyzed 36 choriocarcinoma cases who were treated in our department about their clinical characteristics, and their diagnosis and treatment processes together with the serum β-hCG variation. Results: Analysis showed that the disease onset age, FIGO (International Federation of Gynecology and Obstetrics) stage distribution were similar to the other cohort. The primary origins were uterine canals, and the serum β-hCG elevated with or without vaginal bleeding were common, which all easily lead to misdiagnosis of benign pregnancy related diseases. Our data demonstrated that the misdiagnosis of choriocarcinoma resulted in delaying of the first cycle of chemotherapy, followed by decreased control of serum β-hCG after one chemotherapy cycle and more cycles for serum β-hCG normalization, which meant the possibility of generating chemoresistance. Conclusions: In summary, standardized surveillance and treatment process to decrease misdiagnosis rate of choriocarcinoma can be an effective measure to improve the prognosis of patients. |
| first_indexed | 2024-04-11T14:20:08Z |
| format | Article |
| id | doaj.art-8c3ec6d9987e4c2aacbef27a47e06769 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-11T14:20:08Z |
| publishDate | 2022-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-8c3ec6d9987e4c2aacbef27a47e067692022-12-22T04:19:05ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-07-0149817910.31083/j.ceog4908179S0390-6663(22)01877-2Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 CasesLin-Jing Yuan0Yu-Ying Chen1Cai-Xia Zhu2Yi-Zi Wang3Guo-Fen Yang4Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, 0086-510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, 0086-510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, 0086-510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, 0086-510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, 0086-510080 Guangzhou, Guangdong, ChinaBackground: Choriocarcinoma is a curable malignant neoplasm when chemotherapy is properly implemented. However, when chemotherapy resistance occurs, disease can be fatal. Misdiagnosis is common, which may lead to delaying of the first cycle of chemotherapy and increase the possibility of chemoresistance. Methods: We analyzed 36 choriocarcinoma cases who were treated in our department about their clinical characteristics, and their diagnosis and treatment processes together with the serum β-hCG variation. Results: Analysis showed that the disease onset age, FIGO (International Federation of Gynecology and Obstetrics) stage distribution were similar to the other cohort. The primary origins were uterine canals, and the serum β-hCG elevated with or without vaginal bleeding were common, which all easily lead to misdiagnosis of benign pregnancy related diseases. Our data demonstrated that the misdiagnosis of choriocarcinoma resulted in delaying of the first cycle of chemotherapy, followed by decreased control of serum β-hCG after one chemotherapy cycle and more cycles for serum β-hCG normalization, which meant the possibility of generating chemoresistance. Conclusions: In summary, standardized surveillance and treatment process to decrease misdiagnosis rate of choriocarcinoma can be an effective measure to improve the prognosis of patients.https://www.imrpress.com/journal/CEOG/49/8/10.31083/j.ceog4908179choriocarcinomachemotherapy delaychemoresistance |
| spellingShingle | Lin-Jing Yuan Yu-Ying Chen Cai-Xia Zhu Yi-Zi Wang Guo-Fen Yang Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases Clinical and Experimental Obstetrics & Gynecology choriocarcinoma chemotherapy delay chemoresistance |
| title | Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases |
| title_full | Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases |
| title_fullStr | Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases |
| title_full_unstemmed | Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases |
| title_short | Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases |
| title_sort | misdiagnosis and chemotherapy delaying reduces the chemosensitivity of choriocarcinoma patient analysis of 36 cases |
| topic | choriocarcinoma chemotherapy delay chemoresistance |
| url | https://www.imrpress.com/journal/CEOG/49/8/10.31083/j.ceog4908179 |
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