Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy

Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy

CD147 is highly expressed on the surface of numerous tumor cells to promote invasion and metastasis. Targeting these cells with CD147-specific antibodies has been validated as an effective approach for lung and liver cancer therapy. In the immune system, CD147 is recognized as a co-stimulatory recep...

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Bibliographic Details
Main Authors: Jie-Jie Geng, Juan Tang, Xiang-min Yang, Ruo Chen, Yang Zhang, Kui Zhang, Jin-Lin Miao, Zhi-Nan Chen, Ping Zhu
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:EBioMedicine
Subjects:
BCL11b
Cancer immune-therapy
CD147
Trans-differentiation
Thymocyte development
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417302207

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