Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate.
Non-syndromic orofacial clefts encompass a range of morphological changes affecting the oral cavity and the craniofacial skeleton, of which the genetic and epigenetic etiologic factors remain largely unknown. The objective of this study is to explore the contribution of underlying dentofacial deform...
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MDPI AG
2020-01-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/8/1/2 |
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| author | Denise K Liberton Payal Verma Konstantinia Almpani Peter W Fung Rashmi Mishra Snehlata Oberoi Figen Ç Şenel James K Mah John Huang Bonnie L Padwa Janice S Lee |
| author_facet | Denise K Liberton Payal Verma Konstantinia Almpani Peter W Fung Rashmi Mishra Snehlata Oberoi Figen Ç Şenel James K Mah John Huang Bonnie L Padwa Janice S Lee |
| author_sort | Denise K Liberton |
| collection | DOAJ |
| description | Non-syndromic orofacial clefts encompass a range of morphological changes affecting the oral cavity and the craniofacial skeleton, of which the genetic and epigenetic etiologic factors remain largely unknown. The objective of this study is to explore the contribution of underlying dentofacial deformities (also known as skeletal malocclusions) in the craniofacial morphology of non-syndromic cleft lip and palate patients (nsCLP). For that purpose, geometric morphometric analysis was performed using full skull cone beam computed tomography (CBCT) images of patients with nsCLP (<i>n</i> = 30), normocephalic controls (<i>n</i> = 60), as well as to sex- and ethnicity- matched patients with an equivalent dentofacial deformity (<i>n</i> = 30). Our outcome measures were shape differences among the groups quantified via principal component analysis and associated principal component loadings, as well as mean shape differences quantified via a Procrustes distance among groups. According to our results, despite the shape differences among all three groups, the nsCLP group shares many morphological similarities in the maxilla and mandible with the dentofacial deformity group. Therefore, the dentoskeletal phenotype in nsCLP could be the result of the cleft and the coexisting dentofacial deformity and not simply the impact of the cleft. |
| first_indexed | 2024-12-14T04:22:25Z |
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| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-12-14T04:22:25Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-8c43202b4e214473a2d5352e8fb0032b2022-12-21T23:17:17ZengMDPI AGJournal of Developmental Biology2221-37592020-01-0181210.3390/jdb8010002jdb8010002Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate.Denise K Liberton0Payal Verma1Konstantinia Almpani2Peter W Fung3Rashmi Mishra4Snehlata Oberoi5Figen Ç Şenel6James K Mah7John Huang8Bonnie L Padwa9Janice S Lee10Craniofacial Anomalies and Regeneration Section, NIDCR, NIH, Bethesda, MD 20892-1470, USADivision of Oral & Maxillofacial Surgery, University of Cincinnati, Cincinnati, OH 45267-0558, USACraniofacial Anomalies and Regeneration Section, NIDCR, NIH, Bethesda, MD 20892-1470, USADepartment of Oral & Maxillofacial Surgery, University of North Carolina, Chapel Hill, NC 27599-7450, USADivision of Oral Medicine, University of Washington, Seattle, WA 98195-6370, USAOrofacial Sciences, University of California San Francisco, CA 94143, USAHealth Institutes of Turkey, Turkish Healthcare Quality and Accreditation Institute, 34718 Istanbul, TurkeyAdvanced Education Program in Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Nevada, Las Vegas, NV 89154, USAPrivate Practice Orthodontist, San Leandro, CA 94577, USAHarvard School of Dental Medicine, Oral Surgeon in Chief, Department of Plastic and Oral Surgery, Boston Children’s Hospital, Boston, MA 02115, USACraniofacial Anomalies and Regeneration Section, NIDCR, NIH, Bethesda, MD 20892-1470, USANon-syndromic orofacial clefts encompass a range of morphological changes affecting the oral cavity and the craniofacial skeleton, of which the genetic and epigenetic etiologic factors remain largely unknown. The objective of this study is to explore the contribution of underlying dentofacial deformities (also known as skeletal malocclusions) in the craniofacial morphology of non-syndromic cleft lip and palate patients (nsCLP). For that purpose, geometric morphometric analysis was performed using full skull cone beam computed tomography (CBCT) images of patients with nsCLP (<i>n</i> = 30), normocephalic controls (<i>n</i> = 60), as well as to sex- and ethnicity- matched patients with an equivalent dentofacial deformity (<i>n</i> = 30). Our outcome measures were shape differences among the groups quantified via principal component analysis and associated principal component loadings, as well as mean shape differences quantified via a Procrustes distance among groups. According to our results, despite the shape differences among all three groups, the nsCLP group shares many morphological similarities in the maxilla and mandible with the dentofacial deformity group. Therefore, the dentoskeletal phenotype in nsCLP could be the result of the cleft and the coexisting dentofacial deformity and not simply the impact of the cleft.https://www.mdpi.com/2221-3759/8/1/2non-syndromic cleftcraniofacial morphologymidfacial growthmaxillamandiblemalocclusioncephalometrycomputerized tomography |
| spellingShingle | Denise K Liberton Payal Verma Konstantinia Almpani Peter W Fung Rashmi Mishra Snehlata Oberoi Figen Ç Şenel James K Mah John Huang Bonnie L Padwa Janice S Lee Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate. Journal of Developmental Biology non-syndromic cleft craniofacial morphology midfacial growth maxilla mandible malocclusion cephalometry computerized tomography |
| title | Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate. |
| title_full | Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate. |
| title_fullStr | Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate. |
| title_full_unstemmed | Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate. |
| title_short | Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate. |
| title_sort | craniofacial analysis may indicate co occurrence of skeletal malocclusions and associated risks in development of cleft lip and palate |
| topic | non-syndromic cleft craniofacial morphology midfacial growth maxilla mandible malocclusion cephalometry computerized tomography |
| url | https://www.mdpi.com/2221-3759/8/1/2 |
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