A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of Periodontitis
This meta-analysis intended to assess evidence on the efficacy of locally delivered curcumin/turmeric as an adjunctive to scaling and root planing (SRP), on clinical attachment level (CAL) and probing pocket depth (PPD), compared to SRP alone or in combination with chlorhexidine (CHX). RCTs were ide...
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/481 |
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| author | Louisa M. Wendorff-Tobolla Michael Wolgin Gernot Wagner Irma Klerings Anna Dvornyk Andrej M. Kielbassa |
| author_facet | Louisa M. Wendorff-Tobolla Michael Wolgin Gernot Wagner Irma Klerings Anna Dvornyk Andrej M. Kielbassa |
| author_sort | Louisa M. Wendorff-Tobolla |
| collection | DOAJ |
| description | This meta-analysis intended to assess evidence on the efficacy of locally delivered curcumin/turmeric as an adjunctive to scaling and root planing (SRP), on clinical attachment level (CAL) and probing pocket depth (PPD), compared to SRP alone or in combination with chlorhexidine (CHX). RCTs were identified from PubMed, Cochrane Library, BASE, LIVIVO, Dentistry Oral Sciences Source, MEDLINE Complete, Scopus, ClinicalTrials.gov, and eLibrary, until August 2022. The risk of bias (RoB) was assessed with the Cochrane Risk of Bias tool 2.0. A random-effects meta-analysis was performed by pooling mean differences with 95% confidence intervals. Out of 827 references yielded by the search, 23 trials meeting the eligibility criteria were included. The meta-analysis revealed that SRP and curcumin/turmeric application were statistically significantly different compared to SRP alone for CAL (−0.33 mm; <i>p</i> = 0.03; 95% CI −0.54 to −0.11; I<sup>2</sup> = 62.3%), and for PPD (−0.47 mm; <i>p</i> = 0.024; 95% CI −0.88 to −0.06; I<sup>2</sup> = 95.5%); however, this difference was considered clinically meaningless. No significant differences were obtained between patients treated with SRP and CHX, compared to SRP and curcumin/turmeric. The RoB assessment revealed numerous inaccuracies, thus raising concerns about previous overestimates of potential treatment effects. |
| first_indexed | 2024-03-11T09:07:05Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T09:07:05Z |
| publishDate | 2023-02-01 |
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| series | Biomedicines |
| spelling | doaj.art-8c437119e1c349359cd9311ab915abfe2023-11-16T19:18:53ZengMDPI AGBiomedicines2227-90592023-02-0111248110.3390/biomedicines11020481A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of PeriodontitisLouisa M. Wendorff-Tobolla0Michael Wolgin1Gernot Wagner2Irma Klerings3Anna Dvornyk4Andrej M. Kielbassa5Center for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University (DPU), 3500 Krems, AustriaCenter for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University (DPU), 3500 Krems, AustriaDepartment of Evidence-based Medicine and Evaluation, Danube University Krems, 3500 Krems, AustriaDepartment of Evidence-based Medicine and Evaluation, Danube University Krems, 3500 Krems, AustriaDepartment of Propaedeutics of Therapeutic Dentistry, Faculty of Dentistry, Poltava State Medical University (PSMU), 36011 Poltava, UkraineCenter for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University (DPU), 3500 Krems, AustriaThis meta-analysis intended to assess evidence on the efficacy of locally delivered curcumin/turmeric as an adjunctive to scaling and root planing (SRP), on clinical attachment level (CAL) and probing pocket depth (PPD), compared to SRP alone or in combination with chlorhexidine (CHX). RCTs were identified from PubMed, Cochrane Library, BASE, LIVIVO, Dentistry Oral Sciences Source, MEDLINE Complete, Scopus, ClinicalTrials.gov, and eLibrary, until August 2022. The risk of bias (RoB) was assessed with the Cochrane Risk of Bias tool 2.0. A random-effects meta-analysis was performed by pooling mean differences with 95% confidence intervals. Out of 827 references yielded by the search, 23 trials meeting the eligibility criteria were included. The meta-analysis revealed that SRP and curcumin/turmeric application were statistically significantly different compared to SRP alone for CAL (−0.33 mm; <i>p</i> = 0.03; 95% CI −0.54 to −0.11; I<sup>2</sup> = 62.3%), and for PPD (−0.47 mm; <i>p</i> = 0.024; 95% CI −0.88 to −0.06; I<sup>2</sup> = 95.5%); however, this difference was considered clinically meaningless. No significant differences were obtained between patients treated with SRP and CHX, compared to SRP and curcumin/turmeric. The RoB assessment revealed numerous inaccuracies, thus raising concerns about previous overestimates of potential treatment effects.https://www.mdpi.com/2227-9059/11/2/481chlorhexidineclinical attachment levelcurcumin/turmericmechanical debridementperiodontitisperiodontal treatment |
| spellingShingle | Louisa M. Wendorff-Tobolla Michael Wolgin Gernot Wagner Irma Klerings Anna Dvornyk Andrej M. Kielbassa A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of Periodontitis Biomedicines chlorhexidine clinical attachment level curcumin/turmeric mechanical debridement periodontitis periodontal treatment |
| title | A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of Periodontitis |
| title_full | A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of Periodontitis |
| title_fullStr | A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of Periodontitis |
| title_full_unstemmed | A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of Periodontitis |
| title_short | A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (<i>Curcuma longa</i> L.) in the Treatment of Periodontitis |
| title_sort | systematic review and meta analysis on the efficacy of locally delivered adjunctive curcumin i curcuma longa i l in the treatment of periodontitis |
| topic | chlorhexidine clinical attachment level curcumin/turmeric mechanical debridement periodontitis periodontal treatment |
| url | https://www.mdpi.com/2227-9059/11/2/481 |
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