Circular single-stranded DNA as switchable vector for gene expression in mammalian cells

Circular single-stranded DNA as switchable vector for gene expression in mammalian cells

Abstract Synthetic gene networks in mammalian cells are currently limited to either protein-based transcription factors or RNA-based regulators. Here, we demonstrate a regulatory approach based on circular single-stranded DNA (Css DNA), which can be used as an efficient expression vector with switch...

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Podrobná bibliografie
Hlavní autoři: Linlin Tang, Zhijin Tian, Jin Cheng, Yijing Zhang, Yongxiu Song, Yan Liu, Jinghao Wang, Pengfei Zhang, Yonggang Ke, Friedrich C. Simmel, Jie Song
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2023-10-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-023-42437-6

Internet

https://doi.org/10.1038/s41467-023-42437-6

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