Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in‐vitro and pulmonary hypertension in mice

Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in‐vitro and pulmonary hypertension in mice

Abstract In the lung, communication between pulmonary vascular endothelial cells (PVEC) and pulmonary artery smooth muscle cells (PASMC) is essential for the maintenance of vascular homeostasis. In pulmonary hypertension (PH), the derangement in their cell–cell communication plays a major role in th...

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Bibliographic Details
Main Authors: Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Balaji Ganesh, J. Usha Raj
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Pulmonary Circulation
Subjects:
extracellular vesicles
microRNAs
pulmonary artery smooth muscle cells
pulmonary hypertension
pulmonary vascular endothelial cells
Online Access:https://doi.org/10.1002/pul2.12014

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