Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case Series
There is a wide spectrum of disorders that may originate from different parts of the female genital tract. They are often unique and rare, posing a diagnostic challenge for reporting pathologists. Their uniqueness lies in the rare histomorphologic picture and challenging clinical scenarios, accent...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/18280/63611_CE[Ra1]_F(IS)_QC(SD_SS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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| author | Sanghamitra Mukherjee Debajyoti Singha Roy Vandana Maroo Meghadipa Mandal |
| author_facet | Sanghamitra Mukherjee Debajyoti Singha Roy Vandana Maroo Meghadipa Mandal |
| author_sort | Sanghamitra Mukherjee |
| collection | DOAJ |
| description | There is a wide spectrum of disorders that may originate from different parts of the female genital tract. They are often unique
and rare, posing a diagnostic challenge for reporting pathologists. Their uniqueness lies in the rare histomorphologic picture and
challenging clinical scenarios, accentuated by a paucity of available literature. Sometimes, histomorphology alone may not be
sufficient for diagnosis, and ancillary studies like Immunohistochemistry (IHC) may help arrive at a definitive diagnosis. Present
article represents a series of six unique cases. The first case presented with virilising features and menstrual irregularities. Gross
examination of the adnexal neoplasm showed solid yellowish-orange areas, which were diagnosed as Steroid Cell Tumour (SCT),
Not Otherwise Specified (NOS) based on histomorphology. This diagnosis was further substantiated by diffuse and strong Inhibin
positivity on IHC. The second case presented with huge abdominal distention and markedly raised CA-125 levels. It was diagnosed
as mucinous carcinoma with a focus of Benign Brenner Tumour. The third case presented with postmenopausal bleeding and
underwent radical hysterectomy. Gross examination revealed simultaneous involvement of the unilateral adnexa, and it was finally
diagnosed as endometrioid carcinoma with adnexal metastasis, International Federation of Gynaecology and Obstetrics (FIGO)
stage IIIA. The fourth case was a cervical carcinoma with histomorphology suggestive of high-grade, but it did not fit into any of the
known subtypes of adenocarcinoma. Therefore, it was reported as Adenocarcinoma NOS with focal mucinous differentiation. The
fifth case was a rare cervical Adenosquamous Carcinoma (ASCC) with both malignant squamous and glandular components. The
sixth case was of mesenchymal origin in the vulva, namely Aggressive Angiomyxoma (AA). All these cases highlight the fact that
pathologists should be well aware of these entities to make an appropriate diagnosis. |
| first_indexed | 2024-03-12T13:58:55Z |
| format | Article |
| id | doaj.art-8c46b22a174741198065a071b696854a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-12T13:58:55Z |
| publishDate | 2023-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-8c46b22a174741198065a071b696854a2023-08-22T09:43:40ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-08-01178040910.7860/JCDR/2023/63611.18280Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case SeriesSanghamitra Mukherjee0Debajyoti Singha Roy1Vandana Maroo2Meghadipa Mandal3Associate Professor, Department of Pathology, R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India.Assistant Professor, Department of Pathology, Raiganj Government Medical College, Raiganj, West Bengal, India.Senior Resident, Department of Pathology, Lady Dufferin Victoria Hospital, Kolkata, West Bengal, India.Senior Resident, Department of Pathology, Jhargram Government Medical College and Hospital, Kolkata, West Bengal, India.There is a wide spectrum of disorders that may originate from different parts of the female genital tract. They are often unique and rare, posing a diagnostic challenge for reporting pathologists. Their uniqueness lies in the rare histomorphologic picture and challenging clinical scenarios, accentuated by a paucity of available literature. Sometimes, histomorphology alone may not be sufficient for diagnosis, and ancillary studies like Immunohistochemistry (IHC) may help arrive at a definitive diagnosis. Present article represents a series of six unique cases. The first case presented with virilising features and menstrual irregularities. Gross examination of the adnexal neoplasm showed solid yellowish-orange areas, which were diagnosed as Steroid Cell Tumour (SCT), Not Otherwise Specified (NOS) based on histomorphology. This diagnosis was further substantiated by diffuse and strong Inhibin positivity on IHC. The second case presented with huge abdominal distention and markedly raised CA-125 levels. It was diagnosed as mucinous carcinoma with a focus of Benign Brenner Tumour. The third case presented with postmenopausal bleeding and underwent radical hysterectomy. Gross examination revealed simultaneous involvement of the unilateral adnexa, and it was finally diagnosed as endometrioid carcinoma with adnexal metastasis, International Federation of Gynaecology and Obstetrics (FIGO) stage IIIA. The fourth case was a cervical carcinoma with histomorphology suggestive of high-grade, but it did not fit into any of the known subtypes of adenocarcinoma. Therefore, it was reported as Adenocarcinoma NOS with focal mucinous differentiation. The fifth case was a rare cervical Adenosquamous Carcinoma (ASCC) with both malignant squamous and glandular components. The sixth case was of mesenchymal origin in the vulva, namely Aggressive Angiomyxoma (AA). All these cases highlight the fact that pathologists should be well aware of these entities to make an appropriate diagnosis.https://www.jcdr.net/articles/PDF/18280/63611_CE[Ra1]_F(IS)_QC(SD_SS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdfadenosquamousangiomyxomabrenner tumourendometrioidmucinous carcinomasteroid cell tumour |
| spellingShingle | Sanghamitra Mukherjee Debajyoti Singha Roy Vandana Maroo Meghadipa Mandal Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case Series Journal of Clinical and Diagnostic Research adenosquamous angiomyxoma brenner tumour endometrioid mucinous carcinoma steroid cell tumour |
| title | Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case Series |
| title_full | Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case Series |
| title_fullStr | Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case Series |
| title_full_unstemmed | Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case Series |
| title_short | Rare Diagnoses and Diagnostic Pitfalls in Female Genital Tract Neoplasms: A Case Series |
| title_sort | rare diagnoses and diagnostic pitfalls in female genital tract neoplasms a case series |
| topic | adenosquamous angiomyxoma brenner tumour endometrioid mucinous carcinoma steroid cell tumour |
| url | https://www.jcdr.net/articles/PDF/18280/63611_CE[Ra1]_F(IS)_QC(SD_SS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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