Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection?
The expression of blood group antigens varies across human populations and geographical regions due to natural selection and the influence of environment factors and disease. The red cell membrane is host to numerous surface antigens which are able to influence susceptibility to disease, by acting a...
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MDPI AG
2020-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/4/845 |
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| author | Glenda M. Davison Heather L. Hendrickse Tandi E. Matsha |
| author_facet | Glenda M. Davison Heather L. Hendrickse Tandi E. Matsha |
| author_sort | Glenda M. Davison |
| collection | DOAJ |
| description | The expression of blood group antigens varies across human populations and geographical regions due to natural selection and the influence of environment factors and disease. The red cell membrane is host to numerous surface antigens which are able to influence susceptibility to disease, by acting as receptors for pathogens, or by influencing the immune response. Investigations have shown that Human Immunodeficiency Virus (HIV) can bind and gain entry into erythrocytes, and therefore it is hypothesized that blood groups could play a role in this process. The ABO blood group has been well studied. However, its role in HIV susceptibility remains controversial, while other blood group antigens, and the secretor status of individuals, have been implicated. The Duffy antigen is a chemokine receptor that is important in the inflammatory response. Those who lack this antigen, and type as Duffy null, could therefore be susceptible to HIV infection, especially if associated with neutropenia. Other antigens including those in the Rh, Lutheran and OK blood group systems have all been shown to interact with HIV. More recently, experiments show that cells which overexpress the P<sup>k</sup> antigen appear to be protected against infection. These reports all demonstrate that red cell antigens interact and influence HIV infection. However, as the red cell membrane is complex and the pathogenesis of HIV multi-factorial, the role of blood group antigens cannot be studied in isolation. |
| first_indexed | 2024-03-10T20:47:01Z |
| format | Article |
| id | doaj.art-8c4baa952a9e4b97b753c0a629dcbfd5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:47:01Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8c4baa952a9e4b97b753c0a629dcbfd52023-11-19T20:16:12ZengMDPI AGCells2073-44092020-03-019484510.3390/cells9040845Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection?Glenda M. Davison0Heather L. Hendrickse1Tandi E. Matsha2SAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7530, South AfricaSAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7530, South AfricaSAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7530, South AfricaThe expression of blood group antigens varies across human populations and geographical regions due to natural selection and the influence of environment factors and disease. The red cell membrane is host to numerous surface antigens which are able to influence susceptibility to disease, by acting as receptors for pathogens, or by influencing the immune response. Investigations have shown that Human Immunodeficiency Virus (HIV) can bind and gain entry into erythrocytes, and therefore it is hypothesized that blood groups could play a role in this process. The ABO blood group has been well studied. However, its role in HIV susceptibility remains controversial, while other blood group antigens, and the secretor status of individuals, have been implicated. The Duffy antigen is a chemokine receptor that is important in the inflammatory response. Those who lack this antigen, and type as Duffy null, could therefore be susceptible to HIV infection, especially if associated with neutropenia. Other antigens including those in the Rh, Lutheran and OK blood group systems have all been shown to interact with HIV. More recently, experiments show that cells which overexpress the P<sup>k</sup> antigen appear to be protected against infection. These reports all demonstrate that red cell antigens interact and influence HIV infection. However, as the red cell membrane is complex and the pathogenesis of HIV multi-factorial, the role of blood group antigens cannot be studied in isolation.https://www.mdpi.com/2073-4409/9/4/845red cellsblood group antigensHuman Immunodeficiency Virus |
| spellingShingle | Glenda M. Davison Heather L. Hendrickse Tandi E. Matsha Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection? Cells red cells blood group antigens Human Immunodeficiency Virus |
| title | Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection? |
| title_full | Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection? |
| title_fullStr | Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection? |
| title_full_unstemmed | Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection? |
| title_short | Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection? |
| title_sort | do blood group antigens and the red cell membrane influence human immunodeficiency virus infection |
| topic | red cells blood group antigens Human Immunodeficiency Virus |
| url | https://www.mdpi.com/2073-4409/9/4/845 |
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