The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults
Abstract Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We e...
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| Format: | Article |
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Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10683-1 |
| _version_ | 1817976336792158208 |
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| author | Jean L. Fry Brooke D. Munson Katherine L. Thompson Christopher S. Fry Douglas Paddon-Jones Emily J. Arentson-Lantz |
| author_facet | Jean L. Fry Brooke D. Munson Katherine L. Thompson Christopher S. Fry Douglas Paddon-Jones Emily J. Arentson-Lantz |
| author_sort | Jean L. Fry |
| collection | DOAJ |
| description | Abstract Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated the ability of 10 common genetic variants associated with development of type 2 diabetes to predict impaired glucose metabolism. Our research model was a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inactivity) in a cohort of healthy older adults (n = 31, 65 ± 8 years) with baseline fasting blood glucose < 100 mg/dL. Participants completed a standard 75 g oral glucose tolerance test (OGTT) at baseline and post-bed rest. Bed rest increased 2-h OGTT blood glucose and insulin independent of genetic variant. In multiple regression modeling, the transcription factor 7-like 2 (TCF7L2) rs7903146 T allele predicted increases in 2-h OGTT blood glucose (p = 0.039). We showed that the TCF7L2 rs7903146 T allele confers risk for loss of glucose tolerance in nondiabetic older adults following 7 days of bed rest. |
| first_indexed | 2024-04-13T22:01:22Z |
| format | Article |
| id | doaj.art-8c4c79889e6241089d04dcf6139d8023 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T22:01:22Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8c4c79889e6241089d04dcf6139d80232022-12-22T02:28:05ZengNature PortfolioScientific Reports2045-23222022-04-011211810.1038/s41598-022-10683-1The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adultsJean L. Fry0Brooke D. Munson1Katherine L. Thompson2Christopher S. Fry3Douglas Paddon-Jones4Emily J. Arentson-Lantz5Department of Athletic Training and Clinical Nutrition, University of KentuckyDepartment of Athletic Training and Clinical Nutrition, University of KentuckyDr. Bing Zhang Department of Statistics, University of KentuckyDepartment of Athletic Training and Clinical Nutrition, University of KentuckyDepartment of Nutrition & Metabolism, Center for Rehabilitation, Physical Activity and Nutrition, University of Texas Medical BranchDepartment of Nutrition & Metabolism, Center for Rehabilitation, Physical Activity and Nutrition, University of Texas Medical BranchAbstract Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated the ability of 10 common genetic variants associated with development of type 2 diabetes to predict impaired glucose metabolism. Our research model was a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inactivity) in a cohort of healthy older adults (n = 31, 65 ± 8 years) with baseline fasting blood glucose < 100 mg/dL. Participants completed a standard 75 g oral glucose tolerance test (OGTT) at baseline and post-bed rest. Bed rest increased 2-h OGTT blood glucose and insulin independent of genetic variant. In multiple regression modeling, the transcription factor 7-like 2 (TCF7L2) rs7903146 T allele predicted increases in 2-h OGTT blood glucose (p = 0.039). We showed that the TCF7L2 rs7903146 T allele confers risk for loss of glucose tolerance in nondiabetic older adults following 7 days of bed rest.https://doi.org/10.1038/s41598-022-10683-1 |
| spellingShingle | Jean L. Fry Brooke D. Munson Katherine L. Thompson Christopher S. Fry Douglas Paddon-Jones Emily J. Arentson-Lantz The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults Scientific Reports |
| title | The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults |
| title_full | The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults |
| title_fullStr | The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults |
| title_full_unstemmed | The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults |
| title_short | The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults |
| title_sort | t allele of tcf7l2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults |
| url | https://doi.org/10.1038/s41598-022-10683-1 |
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