Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-chlorobenzofuran-2-carboxamide derivatives <b>VIIa</b>–<b>j</b> prompted us to develop and synthesise a novel series of indole-2-carboxamide derivatives <b>5a</b>–<b&...

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Bibliographic Details
Main Authors: Lamya H. Al-Wahaibi, Yaser A. Mostafa, Mostafa H. Abdelrahman, Ali H. El-Bahrawy, Laurent Trembleau, Bahaa G. M. Youssif
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
indole
carboxamide
apoptosis
antiproliferative
multi-target
Online Access:https://www.mdpi.com/1424-8247/15/8/1006

Internet

https://www.mdpi.com/1424-8247/15/8/1006

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