Mechanical Disturbance of Osteoclasts Induces ATP Release That Leads to Protein Synthesis in Skeletal Muscle through an Akt-mTOR Signaling Pathway

Mechanical Disturbance of Osteoclasts Induces ATP Release That Leads to Protein Synthesis in Skeletal Muscle through an Akt-mTOR Signaling Pathway

Muscle and bone are tightly integrated through mechanical and biochemical signals. Osteoclasts are cells mostly related to pathological bone loss; however, they also start physiological bone remodeling. Therefore, osteoclast signals released during bone remodeling could improve both bone and skeleta...

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Bibliographic Details
Main Authors: Camilo Morales-Jiménez, Julián Balanta-Melo, Manuel Arias-Calderón, Nadia Hernández, Fernán Gómez-Valenzuela, Alejandro Escobar, Enrique Jaimovich, Sonja Buvinic
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
bone-muscle interactions
muscle physiology
bone remodeling
osteoclasts
purinergic signaling
extracellular ATP
Online Access:https://www.mdpi.com/1422-0067/23/16/9444

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