Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and differentiation. The diverse biological roles of HA are linked to the combina...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/8/3/245 |
| _version_ | 1797708882143870976 |
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| author | Mazyar Yazdani Aboulghassem Shahdadfar Catherine Joan Jackson Tor Paaske Utheim |
| author_facet | Mazyar Yazdani Aboulghassem Shahdadfar Catherine Joan Jackson Tor Paaske Utheim |
| author_sort | Mazyar Yazdani |
| collection | DOAJ |
| description | Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and differentiation. The diverse biological roles of HA are linked to the combination of HA’s physicochemical properties and HA-binding proteins. These unique characteristics have encouraged the application of HA-based hydrogel scaffolds for stem cell-based therapy, a successful method in the treatment of limbal stem cell deficiency (LSCD). This condition occurs following direct damage to limbal stem cells and/or changes in the limbal stem cell niche microenvironment due to intrinsic and extrinsic insults. This paper reviews the physical properties, synthesis, and degradation of HA. In addition, the interaction of HA with other extracellular matrix (ECM) components and receptor proteins are discussed. Finally, studies employing HA-based hydrogel scaffolds in the treatment of LSCD are reviewed. |
| first_indexed | 2024-03-12T06:29:07Z |
| format | Article |
| id | doaj.art-8c4dd0ed120f4d5b98a01875511602b9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:29:07Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8c4dd0ed120f4d5b98a01875511602b92023-09-03T01:45:44ZengMDPI AGCells2073-44092019-03-018324510.3390/cells8030245cells8030245Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A ReviewMazyar Yazdani0Aboulghassem Shahdadfar1Catherine Joan Jackson2Tor Paaske Utheim3Department of Medical Biochemistry, Oslo University Hospital, Ullevål, 0450 Oslo, NorwayCenter for Eye Research, Department of Ophthalmology, Oslo University Hospital, Ullevål, 0450 Oslo, NorwayDepartment of Medical Biochemistry, Oslo University Hospital, Ullevål, 0450 Oslo, NorwayDepartment of Medical Biochemistry, Oslo University Hospital, Ullevål, 0450 Oslo, NorwayHyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and differentiation. The diverse biological roles of HA are linked to the combination of HA’s physicochemical properties and HA-binding proteins. These unique characteristics have encouraged the application of HA-based hydrogel scaffolds for stem cell-based therapy, a successful method in the treatment of limbal stem cell deficiency (LSCD). This condition occurs following direct damage to limbal stem cells and/or changes in the limbal stem cell niche microenvironment due to intrinsic and extrinsic insults. This paper reviews the physical properties, synthesis, and degradation of HA. In addition, the interaction of HA with other extracellular matrix (ECM) components and receptor proteins are discussed. Finally, studies employing HA-based hydrogel scaffolds in the treatment of LSCD are reviewed.http://www.mdpi.com/2073-4409/8/3/245hyaluronic acidhyaluronanhydrogel scaffoldsstem cell-based therapytransplantationlimbal stem cell deficiency (LSCD) |
| spellingShingle | Mazyar Yazdani Aboulghassem Shahdadfar Catherine Joan Jackson Tor Paaske Utheim Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review Cells hyaluronic acid hyaluronan hydrogel scaffolds stem cell-based therapy transplantation limbal stem cell deficiency (LSCD) |
| title | Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review |
| title_full | Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review |
| title_fullStr | Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review |
| title_full_unstemmed | Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review |
| title_short | Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review |
| title_sort | hyaluronan based hydrogel scaffolds for limbal stem cell transplantation a review |
| topic | hyaluronic acid hyaluronan hydrogel scaffolds stem cell-based therapy transplantation limbal stem cell deficiency (LSCD) |
| url | http://www.mdpi.com/2073-4409/8/3/245 |
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