Beneficial Effects of O-GlcNAc Stimulation in a Young Rat Model of Sepsis: Beyond Modulation of Gene Expression

Beneficial Effects of O-GlcNAc Stimulation in a Young Rat Model of Sepsis: Beyond Modulation of Gene Expression

The young population, which is particularly at risk of sepsis, is, paradoxically, rarely studied. Acute stimulation of O-GlcNAcylation, a post-translational modification involved in metabolic regulation, cell survival and stress response, is beneficial in young rats with sepsis. Considering that sep...

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Bibliographic Details
Main Authors: Thomas Dupas, Antoine Persello, Angélique Blangy-Letheule, Manon Denis, Angélique Erraud, Virginie Aillerie, Aurélia A. Leroux, Matthieu Rivière, Jacques Lebreton, Arnaud Tessier, Bertrand Rozec, Benjamin Lauzier
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
O-GlcNAcylation
post-translational modification
gene expression
transcriptomic
sepsis
therapeutic strategy
Online Access:https://www.mdpi.com/1422-0067/23/12/6430

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