Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review
Endophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/7/2/147 |
| _version_ | 1797396256240173056 |
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| author | Bartholomew Saanu Adeleke Olubukola Oluranti Babalola |
| author_facet | Bartholomew Saanu Adeleke Olubukola Oluranti Babalola |
| author_sort | Bartholomew Saanu Adeleke |
| collection | DOAJ |
| description | Endophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotics is increasing, thus limiting the therapeutic potential and effectiveness of antibiotics. Consequently, the need to search for novel, affordable and nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms to meet human needs is essential. Fungal endophytes produce invaluable bioactive metabolic compounds beneficial to humans with antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some of these bioactive compounds include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone etc. Despite the aforementioned importance of endophytic fungal metabolites, less information is available on their exploration and pharmacological importance. Therefore, in this review, we shall elucidate the fungal bioactive metabolites from medicinal plants and their pharmacological potential. |
| first_indexed | 2024-03-09T00:47:44Z |
| format | Article |
| id | doaj.art-8c4f4b6562e543d498f035935940e0d5 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T00:47:44Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-8c4f4b6562e543d498f035935940e0d52023-12-11T17:24:11ZengMDPI AGJournal of Fungi2309-608X2021-02-017214710.3390/jof7020147Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A ReviewBartholomew Saanu Adeleke0Olubukola Oluranti Babalola1Food Security and Safety Niche Area, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho 2735, South AfricaFood Security and Safety Niche Area, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho 2735, South AfricaEndophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotics is increasing, thus limiting the therapeutic potential and effectiveness of antibiotics. Consequently, the need to search for novel, affordable and nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms to meet human needs is essential. Fungal endophytes produce invaluable bioactive metabolic compounds beneficial to humans with antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some of these bioactive compounds include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone etc. Despite the aforementioned importance of endophytic fungal metabolites, less information is available on their exploration and pharmacological importance. Therefore, in this review, we shall elucidate the fungal bioactive metabolites from medicinal plants and their pharmacological potential.https://www.mdpi.com/2309-608X/7/2/147antibioticsantimicrobialfungal metabolitesmedicinal plantspharmacology |
| spellingShingle | Bartholomew Saanu Adeleke Olubukola Oluranti Babalola Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review Journal of Fungi antibiotics antimicrobial fungal metabolites medicinal plants pharmacology |
| title | Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review |
| title_full | Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review |
| title_fullStr | Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review |
| title_full_unstemmed | Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review |
| title_short | Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review |
| title_sort | pharmacological potential of fungal endophytes associated with medicinal plants a review |
| topic | antibiotics antimicrobial fungal metabolites medicinal plants pharmacology |
| url | https://www.mdpi.com/2309-608X/7/2/147 |
| work_keys_str_mv | AT bartholomewsaanuadeleke pharmacologicalpotentialoffungalendophytesassociatedwithmedicinalplantsareview AT olubukolaolurantibabalola pharmacologicalpotentialoffungalendophytesassociatedwithmedicinalplantsareview |