Marine Natural Products: A Source of Novel Anticancer Drugs
Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent r...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/9/491 |
| _version_ | 1811187661762723840 |
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| author | Shaden A. M. Khalifa Nizar Elias Mohamed A. Farag Lei Chen Aamer Saeed Mohamed-Elamir F. Hegazy Moustafa S. Moustafa Aida Abd El-Wahed Saleh M. Al-Mousawi Syed G. Musharraf Fang-Rong Chang Arihiro Iwasaki Kiyotake Suenaga Muaaz Alajlani Ulf Göransson Hesham R. El-Seedi |
| author_facet | Shaden A. M. Khalifa Nizar Elias Mohamed A. Farag Lei Chen Aamer Saeed Mohamed-Elamir F. Hegazy Moustafa S. Moustafa Aida Abd El-Wahed Saleh M. Al-Mousawi Syed G. Musharraf Fang-Rong Chang Arihiro Iwasaki Kiyotake Suenaga Muaaz Alajlani Ulf Göransson Hesham R. El-Seedi |
| author_sort | Shaden A. M. Khalifa |
| collection | DOAJ |
| description | Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed. |
| first_indexed | 2024-04-11T14:07:09Z |
| format | Article |
| id | doaj.art-8c4f4f198ca5429f9f50c1fca954a1be |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T14:07:09Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8c4f4f198ca5429f9f50c1fca954a1be2022-12-22T04:19:51ZengMDPI AGMarine Drugs1660-33972019-08-0117949110.3390/md17090491md17090491Marine Natural Products: A Source of Novel Anticancer DrugsShaden A. M. Khalifa0Nizar Elias1Mohamed A. Farag2Lei Chen3Aamer Saeed4Mohamed-Elamir F. Hegazy5Moustafa S. Moustafa6Aida Abd El-Wahed7Saleh M. Al-Mousawi8Syed G. Musharraf9Fang-Rong Chang10Arihiro Iwasaki11Kiyotake Suenaga12Muaaz Alajlani13Ulf Göransson14Hesham R. El-Seedi15Clinical Research Centre, Karolinska University Hospital, Novum, 14157 Huddinge, Stockholm, SwedenDepartment of Laboratory Medicine, Faculty of Medicine, University of Kalamoon, P.O. Box 222 Dayr Atiyah, SyriaPharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini St., P.B. 11562 Cairo, EgyptCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaDepartment of Chemitry, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudingerweg 5, 55128 Mainz, GermanyDepartment of Chemistry, Faculty of Science, University of Kuwait, 13060 Safat, KuwaitDepartment of Chemistry, Faculty of Science, University of Kuwait, 13060 Safat, KuwaitDepartment of Chemistry, Faculty of Science, University of Kuwait, 13060 Safat, KuwaitH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, PakistanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, JapanDepartment of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, JapanDepartment of Pharmaceutical Biology/Pharmacognosy, Institute of Pharmacy, University of HalleWittenberg, Hoher Weg 8, DE 06120 Halle (Saale), GermanyPharmacognosy, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-75 123 Uppsala, SwedenPharmacognosy, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-75 123 Uppsala, SwedenCancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.https://www.mdpi.com/1660-3397/17/9/491marineplantsmicroorganismantitumoranticancercytotoxicclinical trialsdrugs |
| spellingShingle | Shaden A. M. Khalifa Nizar Elias Mohamed A. Farag Lei Chen Aamer Saeed Mohamed-Elamir F. Hegazy Moustafa S. Moustafa Aida Abd El-Wahed Saleh M. Al-Mousawi Syed G. Musharraf Fang-Rong Chang Arihiro Iwasaki Kiyotake Suenaga Muaaz Alajlani Ulf Göransson Hesham R. El-Seedi Marine Natural Products: A Source of Novel Anticancer Drugs Marine Drugs marine plants microorganism antitumor anticancer cytotoxic clinical trials drugs |
| title | Marine Natural Products: A Source of Novel Anticancer Drugs |
| title_full | Marine Natural Products: A Source of Novel Anticancer Drugs |
| title_fullStr | Marine Natural Products: A Source of Novel Anticancer Drugs |
| title_full_unstemmed | Marine Natural Products: A Source of Novel Anticancer Drugs |
| title_short | Marine Natural Products: A Source of Novel Anticancer Drugs |
| title_sort | marine natural products a source of novel anticancer drugs |
| topic | marine plants microorganism antitumor anticancer cytotoxic clinical trials drugs |
| url | https://www.mdpi.com/1660-3397/17/9/491 |
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