Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair
In orthopedics, the repair of bone defects remains challenging. In previous research reports, magnesium phosphate cements (MPCs) were widely used because of their excellent mechanical properties, which have been widely used in the field of orthopedic medicine. We built a new k-struvite (MPC) cement...
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/2/344 |
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| author | Yinchu Liu Ling Yu Jingteng Chen Shiyu Li Zhun Wei Weichun Guo |
| author_facet | Yinchu Liu Ling Yu Jingteng Chen Shiyu Li Zhun Wei Weichun Guo |
| author_sort | Yinchu Liu |
| collection | DOAJ |
| description | In orthopedics, the repair of bone defects remains challenging. In previous research reports, magnesium phosphate cements (MPCs) were widely used because of their excellent mechanical properties, which have been widely used in the field of orthopedic medicine. We built a new k-struvite (MPC) cement obtained from zinc oxide (ZnO) and assessed its osteogenic properties. Zinc-doped magnesium phosphate cement (ZMPC) is a novel material with good biocompatibility and degradability. This article summarizes the preparation method, physicochemical properties, and biological properties of ZMPC through research on this material. The results show that ZMPC has the same strength and toughness (25.3 ± 1.73 MPa to 20.18 ± 2.11 MPa), that meet the requirements of bone repair. Furthermore, the material can gradually degrade (12.27% ± 1.11% in 28 days) and promote osteogenic differentiation (relative protein expression level increased 2–3 times) of rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. In addition, in vivo confirmation revealed increased bone regeneration in a rat calvarial defect model compared with MPC alone. Therefore, ZMPC has broad application prospects and is expected to be an important repair material in the field of orthopedic medicine. |
| first_indexed | 2024-03-07T22:41:48Z |
| format | Article |
| id | doaj.art-8c4f627d014e4a85bb91436efbefb766 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-07T22:41:48Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8c4f627d014e4a85bb91436efbefb7662024-02-23T15:08:33ZengMDPI AGBiomedicines2227-90592024-02-0112234410.3390/biomedicines12020344Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect RepairYinchu Liu0Ling Yu1Jingteng Chen2Shiyu Li3Zhun Wei4Weichun Guo5Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaIn orthopedics, the repair of bone defects remains challenging. In previous research reports, magnesium phosphate cements (MPCs) were widely used because of their excellent mechanical properties, which have been widely used in the field of orthopedic medicine. We built a new k-struvite (MPC) cement obtained from zinc oxide (ZnO) and assessed its osteogenic properties. Zinc-doped magnesium phosphate cement (ZMPC) is a novel material with good biocompatibility and degradability. This article summarizes the preparation method, physicochemical properties, and biological properties of ZMPC through research on this material. The results show that ZMPC has the same strength and toughness (25.3 ± 1.73 MPa to 20.18 ± 2.11 MPa), that meet the requirements of bone repair. Furthermore, the material can gradually degrade (12.27% ± 1.11% in 28 days) and promote osteogenic differentiation (relative protein expression level increased 2–3 times) of rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. In addition, in vivo confirmation revealed increased bone regeneration in a rat calvarial defect model compared with MPC alone. Therefore, ZMPC has broad application prospects and is expected to be an important repair material in the field of orthopedic medicine.https://www.mdpi.com/2227-9059/12/2/344bone defectzinc-doped magnesium phosphate cementbone repairosteogenic differentiationrat bone marrow mesenchymal stem cells |
| spellingShingle | Yinchu Liu Ling Yu Jingteng Chen Shiyu Li Zhun Wei Weichun Guo Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair Biomedicines bone defect zinc-doped magnesium phosphate cement bone repair osteogenic differentiation rat bone marrow mesenchymal stem cells |
| title | Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair |
| title_full | Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair |
| title_fullStr | Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair |
| title_full_unstemmed | Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair |
| title_short | Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair |
| title_sort | exploring the osteogenic potential of zinc doped magnesium phosphate cement zmpc a novel material for orthopedic bone defect repair |
| topic | bone defect zinc-doped magnesium phosphate cement bone repair osteogenic differentiation rat bone marrow mesenchymal stem cells |
| url | https://www.mdpi.com/2227-9059/12/2/344 |
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