Landscape of Epidermal Growth Factor Receptor Heterodimers in Brain Metastases

Landscape of Epidermal Growth Factor Receptor Heterodimers in Brain Metastases

HER2+ breast cancer patients have an elevated risk of developing brain metastases (BM), despite adjuvant HER2-targeted therapy. The mechanisms underpinning this reduced intracranial efficacy are unclear. We optimised the in situ proximity ligation assay (PLA) for detection of the high-affinity neure...

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Bibliographic Details
Main Authors: Malcolm Lim, Tam H. Nguyen, Colleen Niland, Lynne E. Reid, Parmjit S. Jat, Jodi M. Saunus, Sunil R. Lakhani
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
brain metastases
HER family
HER dimers
breast cancer
proximity ligation assay
Online Access:https://www.mdpi.com/2072-6694/14/3/533

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