DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.
<h4>Background</h4>Induction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of patients with locoregion...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25019640/?tool=EBI |
| _version_ | 1819240758168780800 |
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| author | Tanguy Y Seiwert XiaoZhe Wang Jana Heitmann Vivian Villegas-Bergazzi Kam Sprott Stephen Finn Esther O'Regan Allan D Farrow Ralph R Weichselbaum Mark W Lingen Ezra E W Cohen Kerstin Stenson David T Weaver Everett E Vokes |
| author_facet | Tanguy Y Seiwert XiaoZhe Wang Jana Heitmann Vivian Villegas-Bergazzi Kam Sprott Stephen Finn Esther O'Regan Allan D Farrow Ralph R Weichselbaum Mark W Lingen Ezra E W Cohen Kerstin Stenson David T Weaver Everett E Vokes |
| author_sort | Tanguy Y Seiwert |
| collection | DOAJ |
| description | <h4>Background</h4>Induction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of patients with locoregionally-advanced HNC to induction chemotherapy by evaluating the expression pattern of DNA repair proteins.<h4>Methods</h4>Expression of a panel of DNA-repair proteins in formalin-fixed paraffin embedded specimens from a cohort of 37 HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation were analyzed using quantitative immunohistochemistry.<h4>Results</h4>We found that XPF (an ERCC1 binding partner) and phospho-MAPKAP Kinase 2 (pMK2) are novel biomarkers for HNSCC patients undergoing platinum-based induction chemotherapy. Low XPF expression in HNSCC patients is associated with better response to induction chemoradiotherapy, while high XPF expression correlates with a worse response (p = 0.02). Furthermore, low pMK2 expression was found to correlate significantly with overall survival after induction plus chemoradiation therapy (p = 0.01), suggesting that pMK2 may relate to chemoradiation therapy.<h4>Conclusions</h4>We identified XPF and pMK2 as novel DNA-repair biomarkers for locoregionally-advanced HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation. Our study provides insights for the use of DNA repair biomarkers in personalized diagnostics strategies. Further validation in a larger cohort is indicated. |
| first_indexed | 2024-12-23T14:13:06Z |
| format | Article |
| id | doaj.art-8c508f0d8e494bdca4110695a9b7a55c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T14:13:06Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8c508f0d8e494bdca4110695a9b7a55c2022-12-21T17:44:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10211210.1371/journal.pone.0102112DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.Tanguy Y SeiwertXiaoZhe WangJana HeitmannVivian Villegas-BergazziKam SprottStephen FinnEsther O'ReganAllan D FarrowRalph R WeichselbaumMark W LingenEzra E W CohenKerstin StensonDavid T WeaverEverett E Vokes<h4>Background</h4>Induction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of patients with locoregionally-advanced HNC to induction chemotherapy by evaluating the expression pattern of DNA repair proteins.<h4>Methods</h4>Expression of a panel of DNA-repair proteins in formalin-fixed paraffin embedded specimens from a cohort of 37 HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation were analyzed using quantitative immunohistochemistry.<h4>Results</h4>We found that XPF (an ERCC1 binding partner) and phospho-MAPKAP Kinase 2 (pMK2) are novel biomarkers for HNSCC patients undergoing platinum-based induction chemotherapy. Low XPF expression in HNSCC patients is associated with better response to induction chemoradiotherapy, while high XPF expression correlates with a worse response (p = 0.02). Furthermore, low pMK2 expression was found to correlate significantly with overall survival after induction plus chemoradiation therapy (p = 0.01), suggesting that pMK2 may relate to chemoradiation therapy.<h4>Conclusions</h4>We identified XPF and pMK2 as novel DNA-repair biomarkers for locoregionally-advanced HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation. Our study provides insights for the use of DNA repair biomarkers in personalized diagnostics strategies. Further validation in a larger cohort is indicated.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25019640/?tool=EBI |
| spellingShingle | Tanguy Y Seiwert XiaoZhe Wang Jana Heitmann Vivian Villegas-Bergazzi Kam Sprott Stephen Finn Esther O'Regan Allan D Farrow Ralph R Weichselbaum Mark W Lingen Ezra E W Cohen Kerstin Stenson David T Weaver Everett E Vokes DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. PLoS ONE |
| title | DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_full | DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_fullStr | DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_full_unstemmed | DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_short | DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_sort | dna repair biomarkers xpf and phospho mapkap kinase 2 correlate with clinical outcome in advanced head and neck cancer |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25019640/?tool=EBI |
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