HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice
Adult neurogenesis, a striking form of neural plasticity, is involved in the modulation of social stimuli driving reproduction. Previous studies on adult neurogenesis have shown that this process is significantly modulated around puberty in female mice. Puberty is a critical developmental period tri...
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| Format: | Article |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2020.584493/full |
| _version_ | 1818352042275504128 |
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| author | Sara Trova Sara Trova Serena Bovetti Giuliana Pellegrino Sara Bonzano Paolo Giacobini Paolo Peretto |
| author_facet | Sara Trova Sara Trova Serena Bovetti Giuliana Pellegrino Sara Bonzano Paolo Giacobini Paolo Peretto |
| author_sort | Sara Trova |
| collection | DOAJ |
| description | Adult neurogenesis, a striking form of neural plasticity, is involved in the modulation of social stimuli driving reproduction. Previous studies on adult neurogenesis have shown that this process is significantly modulated around puberty in female mice. Puberty is a critical developmental period triggered by increased secretion of the gonadotropin releasing hormone (GnRH), which controls the activity of the hypothalamic-pituitary-gonadal axis (HPG). Secretion of HPG-axis factors at puberty participates to the refinement of neural circuits that govern reproduction. Here, by exploiting a transgenic GnRH deficient mouse model, that progressively loses GnRH expression during postnatal development (GnRH::Cre;DicerloxP/loxPmice), we found that a postnatally-acquired dysfunction in the GnRH system affects adult neurogenesis selectively in the subventricular-zone neurogenic niche in a sexually dimorphic way. Moreover, by examining adult females ovariectomized before the onset of puberty, we provide important evidence that, among the HPG-axis secreting factors, the circulating levels of gonadal hormones during pre-/peri-pubertal life contribute to set-up the proper adult subventricular zone-olfactory bulb neurogenic system. |
| first_indexed | 2024-12-13T18:47:20Z |
| format | Article |
| id | doaj.art-8c54fd3f537f4779b2630c2f1f4bde62 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-13T18:47:20Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-8c54fd3f537f4779b2630c2f1f4bde622022-12-21T23:35:02ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292020-11-011410.3389/fnana.2020.584493584493HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in MiceSara Trova0Sara Trova1Serena Bovetti2Giuliana Pellegrino3Sara Bonzano4Paolo Giacobini5Paolo Peretto6Department of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Orbassano, ItalyUniv.Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, Laboratory of the Development and Plasticity of Neuroendocrine Brain, Lille, FranceDepartment of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Orbassano, ItalyUniv.Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, Laboratory of the Development and Plasticity of Neuroendocrine Brain, Lille, FranceDepartment of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Orbassano, ItalyUniv.Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience and Cognition, Laboratory of the Development and Plasticity of Neuroendocrine Brain, Lille, FranceDepartment of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Orbassano, ItalyAdult neurogenesis, a striking form of neural plasticity, is involved in the modulation of social stimuli driving reproduction. Previous studies on adult neurogenesis have shown that this process is significantly modulated around puberty in female mice. Puberty is a critical developmental period triggered by increased secretion of the gonadotropin releasing hormone (GnRH), which controls the activity of the hypothalamic-pituitary-gonadal axis (HPG). Secretion of HPG-axis factors at puberty participates to the refinement of neural circuits that govern reproduction. Here, by exploiting a transgenic GnRH deficient mouse model, that progressively loses GnRH expression during postnatal development (GnRH::Cre;DicerloxP/loxPmice), we found that a postnatally-acquired dysfunction in the GnRH system affects adult neurogenesis selectively in the subventricular-zone neurogenic niche in a sexually dimorphic way. Moreover, by examining adult females ovariectomized before the onset of puberty, we provide important evidence that, among the HPG-axis secreting factors, the circulating levels of gonadal hormones during pre-/peri-pubertal life contribute to set-up the proper adult subventricular zone-olfactory bulb neurogenic system.https://www.frontiersin.org/articles/10.3389/fnana.2020.584493/fulladult neurogenesispubertyhypothalamus-pituitary-gonadal axisGnRHsubventricular zonedentate gyrus |
| spellingShingle | Sara Trova Sara Trova Serena Bovetti Giuliana Pellegrino Sara Bonzano Paolo Giacobini Paolo Peretto HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice Frontiers in Neuroanatomy adult neurogenesis puberty hypothalamus-pituitary-gonadal axis GnRH subventricular zone dentate gyrus |
| title | HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice |
| title_full | HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice |
| title_fullStr | HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice |
| title_full_unstemmed | HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice |
| title_short | HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice |
| title_sort | hpg dependent peri pubertal regulation of adult neurogenesis in mice |
| topic | adult neurogenesis puberty hypothalamus-pituitary-gonadal axis GnRH subventricular zone dentate gyrus |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2020.584493/full |
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