Serum Folate deficiency in HCV related Hepatocellular Carcinoma
Abstract Nutritional and environmental factors had been reporting in the progression of hepatocellular carcinoma (HCC). In this study, we focused our intervention in the correlation between the folate status and the progression of HCC in patients with chronic virus C (HCV) infection. Nine-eight pati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09030-1 |
| _version_ | 1811335443556335616 |
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| author | Giulia Malaguarnera Vito Emanuele Catania Gaetano Bertino Filippo Drago Roberto Madeddu Claudia Bonfiglio Michele Malaguarnera |
| author_facet | Giulia Malaguarnera Vito Emanuele Catania Gaetano Bertino Filippo Drago Roberto Madeddu Claudia Bonfiglio Michele Malaguarnera |
| author_sort | Giulia Malaguarnera |
| collection | DOAJ |
| description | Abstract Nutritional and environmental factors had been reporting in the progression of hepatocellular carcinoma (HCC). In this study, we focused our intervention in the correlation between the folate status and the progression of HCC in patients with chronic virus C (HCV) infection. Nine-eight patients, HCV positive with HCC and one hundred of patients with HCV positive liver cirrhosis (LC) and one hundred patients with HCV positive chronic hepatitis (CHC) and one hundred control subjects were enrolled. The viremia for hepatitis C patients (HCV) was determined by HCV RNA with polymerase chain reaction. HCV was confirmed by HCV RNA or a positive anti-HCV test with chronic liver disease. The comparison of folate serum levels in HCC patients vs Liver Cirrhosis (LC) patients showed a significant decrease of 1.16 ng/ml P = 0.0006 (95% CI-1.925 to − 0.395), in HCC patients versus CHC a decrease of 1.40 ng/ml P < 0.0001 (95% CI-2.16 to − 0.63), in HCC vs controls a decrease of 3.80 ng/ml P < 0.0001 (95% CI-4.56 to − 3.03). The comparison of homocysteine Hcy serum levels showed a significant increase in HCC vs LC of 4 nmol/L (P < 0.0001, 95% CI 2.77 to 5.22) versus CHC of 9 nmol/L (P < 0.0001, 95% CI 7.78 to 10.22) and vs Controls 9.30 nmol/L (P < 0.0001, 95% CI 8.07 to 10.52). With progression of HCV infection from chronic hepatitis to cirrhosis, then to HCC development, serum folate levels are progressively decreasing together with a progressive increase in serum homocysteine levels reflecting its role in disease progress and carcinogenesis. |
| first_indexed | 2024-04-13T17:24:18Z |
| format | Article |
| id | doaj.art-8c56b57922f146308e3645dd96fbf07c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T17:24:18Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8c56b57922f146308e3645dd96fbf07c2022-12-22T02:37:51ZengNature PortfolioScientific Reports2045-23222022-03-0112111010.1038/s41598-022-09030-1Serum Folate deficiency in HCV related Hepatocellular CarcinomaGiulia Malaguarnera0Vito Emanuele Catania1Gaetano Bertino2Filippo Drago3Roberto Madeddu4Claudia Bonfiglio5Michele Malaguarnera6Department of Biomedical and Biotechnological Science, University of CataniaMedical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of CataniaDepartment of Experimental and Clinical Medicine, University of Catania, Policlinico “G. Rodolico”Department of Biomedical and Biotechnological Science, University of CataniaDepartment of Biomedical Sciences, University of SassariMedical Centre INPS Catania-ItalyDepartment of Biomedical and Biotechnological Science, University of CataniaAbstract Nutritional and environmental factors had been reporting in the progression of hepatocellular carcinoma (HCC). In this study, we focused our intervention in the correlation between the folate status and the progression of HCC in patients with chronic virus C (HCV) infection. Nine-eight patients, HCV positive with HCC and one hundred of patients with HCV positive liver cirrhosis (LC) and one hundred patients with HCV positive chronic hepatitis (CHC) and one hundred control subjects were enrolled. The viremia for hepatitis C patients (HCV) was determined by HCV RNA with polymerase chain reaction. HCV was confirmed by HCV RNA or a positive anti-HCV test with chronic liver disease. The comparison of folate serum levels in HCC patients vs Liver Cirrhosis (LC) patients showed a significant decrease of 1.16 ng/ml P = 0.0006 (95% CI-1.925 to − 0.395), in HCC patients versus CHC a decrease of 1.40 ng/ml P < 0.0001 (95% CI-2.16 to − 0.63), in HCC vs controls a decrease of 3.80 ng/ml P < 0.0001 (95% CI-4.56 to − 3.03). The comparison of homocysteine Hcy serum levels showed a significant increase in HCC vs LC of 4 nmol/L (P < 0.0001, 95% CI 2.77 to 5.22) versus CHC of 9 nmol/L (P < 0.0001, 95% CI 7.78 to 10.22) and vs Controls 9.30 nmol/L (P < 0.0001, 95% CI 8.07 to 10.52). With progression of HCV infection from chronic hepatitis to cirrhosis, then to HCC development, serum folate levels are progressively decreasing together with a progressive increase in serum homocysteine levels reflecting its role in disease progress and carcinogenesis.https://doi.org/10.1038/s41598-022-09030-1 |
| spellingShingle | Giulia Malaguarnera Vito Emanuele Catania Gaetano Bertino Filippo Drago Roberto Madeddu Claudia Bonfiglio Michele Malaguarnera Serum Folate deficiency in HCV related Hepatocellular Carcinoma Scientific Reports |
| title | Serum Folate deficiency in HCV related Hepatocellular Carcinoma |
| title_full | Serum Folate deficiency in HCV related Hepatocellular Carcinoma |
| title_fullStr | Serum Folate deficiency in HCV related Hepatocellular Carcinoma |
| title_full_unstemmed | Serum Folate deficiency in HCV related Hepatocellular Carcinoma |
| title_short | Serum Folate deficiency in HCV related Hepatocellular Carcinoma |
| title_sort | serum folate deficiency in hcv related hepatocellular carcinoma |
| url | https://doi.org/10.1038/s41598-022-09030-1 |
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