Presence of cell-free fetal circRNA in maternal plasma
Introduction There is an urgent need to find novel stable cell-free fetal (cff)-RNA in the maternal circulation to facilitate the advance of non-invasive prenatal testing (NIPT) to more effectively avoid birth defects. Material and methods CircRNA microarray was used to detect the cff-circRNA in pl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2022-02-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Presence-of-cell-free-fetal-circRNA-in-maternal-plasma,146204,0,2.html |
| _version_ | 1797998119157235712 |
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| author | Yuxin Ran Ruixin Chen Yangyu Zhao Nanlin Yin Hongbo Qi |
| author_facet | Yuxin Ran Ruixin Chen Yangyu Zhao Nanlin Yin Hongbo Qi |
| author_sort | Yuxin Ran |
| collection | DOAJ |
| description | Introduction
There is an urgent need to find novel stable cell-free fetal (cff)-RNA in the maternal circulation to facilitate the advance of non-invasive prenatal testing (NIPT) to more effectively avoid birth defects.
Material and methods
CircRNA microarray was used to detect the cff-circRNA in plasma.
Results
There were cff-circRNAs from the fetus in the peripheral blood of pregnant women and persisted even until at least 24 hours after delivery. In addition, we found that cff-circRNA might have a specific expression pattern in gestational disease.
Conclusions
We demonstrated the presence of cff-circRNA in the maternal circulation that may shed new light on the development of NIPT. |
| first_indexed | 2024-04-11T10:43:28Z |
| format | Article |
| id | doaj.art-8c56eaf0b1f84aaf95e777e9ea6e2de5 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-04-11T10:43:28Z |
| publishDate | 2022-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-8c56eaf0b1f84aaf95e777e9ea6e2de52022-12-22T04:29:08ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512022-02-0118254054410.5114/aoms/146204146204Presence of cell-free fetal circRNA in maternal plasmaYuxin Ran0Ruixin Chen1Yangyu Zhao2Nanlin Yin3Hongbo Qi4Department of Obstetrics, The First Afliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Obstetrics, The First Afliated Hospital of Chongqing Medical University, Chongqing, ChinaIntroduction There is an urgent need to find novel stable cell-free fetal (cff)-RNA in the maternal circulation to facilitate the advance of non-invasive prenatal testing (NIPT) to more effectively avoid birth defects. Material and methods CircRNA microarray was used to detect the cff-circRNA in plasma. Results There were cff-circRNAs from the fetus in the peripheral blood of pregnant women and persisted even until at least 24 hours after delivery. In addition, we found that cff-circRNA might have a specific expression pattern in gestational disease. Conclusions We demonstrated the presence of cff-circRNA in the maternal circulation that may shed new light on the development of NIPT.https://www.archivesofmedicalscience.com/Presence-of-cell-free-fetal-circRNA-in-maternal-plasma,146204,0,2.htmlnoninvasive prenatal testingcell-free fetal circrnamaternal-fetal communication |
| spellingShingle | Yuxin Ran Ruixin Chen Yangyu Zhao Nanlin Yin Hongbo Qi Presence of cell-free fetal circRNA in maternal plasma Archives of Medical Science noninvasive prenatal testing cell-free fetal circrna maternal-fetal communication |
| title | Presence of cell-free fetal circRNA in maternal plasma |
| title_full | Presence of cell-free fetal circRNA in maternal plasma |
| title_fullStr | Presence of cell-free fetal circRNA in maternal plasma |
| title_full_unstemmed | Presence of cell-free fetal circRNA in maternal plasma |
| title_short | Presence of cell-free fetal circRNA in maternal plasma |
| title_sort | presence of cell free fetal circrna in maternal plasma |
| topic | noninvasive prenatal testing cell-free fetal circrna maternal-fetal communication |
| url | https://www.archivesofmedicalscience.com/Presence-of-cell-free-fetal-circRNA-in-maternal-plasma,146204,0,2.html |
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