Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers
Histiocytic sarcoma (HS) is an aggressive malignant tumor of histiocytes, which can affect almost any organ in the body and is characterized by a broad array of tumor locations and clinical presentations. So far, no complete overview exists of the array of clinical aspects of HS in specific dog bree...
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MDPI AG
2022-09-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/9/498 |
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| author | Suzanne A. Erich Jane M. Dobson Erik Teske |
| author_facet | Suzanne A. Erich Jane M. Dobson Erik Teske |
| author_sort | Suzanne A. Erich |
| collection | DOAJ |
| description | Histiocytic sarcoma (HS) is an aggressive malignant tumor of histiocytes, which can affect almost any organ in the body and is characterized by a broad array of tumor locations and clinical presentations. So far, no complete overview exists of the array of clinical aspects of HS in specific dog breeds in large groups. Therefore, we investigated the clinical characteristics of HS in a population of Bernese Mountain Dogs (BMD; n = 365) and Flat-Coated Retrievers (FCR; n = 289), which are two of the most affected dog breeds. Cases were selected from databases from different pathology services, and clinical information was retrospectively collected for each case. Localized HS was reported significantly more frequently in the FCR (60.6%) than in the BMD (39.2%), and disseminated HS was recorded significantly more frequently in the BMD (60.8%) than in the FCR (39.4%). Lameness was seen more often in FCR than in BMD, and the vast majority (78.1%) of LHS leading to lameness was located in the front legs in the FCR, while in the BMD, there was a more even distribution. BMD had significantly more often leukocytosis and thrombocytopenia, even corrected for the type of HS, than FCR. No significant difference in the frequency of anemia was recorded between BMD and FCR. In those dogs in which blood examination was performed, hypercalcemia was diagnosed in 15 BMD, while none of the FCR had hypercalcemia. The new information provided in this study can aid the diagnostic process and allow for prompt treatment recommendations. |
| first_indexed | 2024-03-09T22:15:28Z |
| format | Article |
| id | doaj.art-8c56f7768d34495e83a11d7b27b6d7bb |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T22:15:28Z |
| publishDate | 2022-09-01 |
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| series | Veterinary Sciences |
| spelling | doaj.art-8c56f7768d34495e83a11d7b27b6d7bb2023-11-23T19:24:26ZengMDPI AGVeterinary Sciences2306-73812022-09-019949810.3390/vetsci9090498Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated RetrieversSuzanne A. Erich0Jane M. Dobson1Erik Teske2Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80154, 3508TD Utrecht, The NetherlandsDepartment of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UKDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80154, 3508TD Utrecht, The NetherlandsHistiocytic sarcoma (HS) is an aggressive malignant tumor of histiocytes, which can affect almost any organ in the body and is characterized by a broad array of tumor locations and clinical presentations. So far, no complete overview exists of the array of clinical aspects of HS in specific dog breeds in large groups. Therefore, we investigated the clinical characteristics of HS in a population of Bernese Mountain Dogs (BMD; n = 365) and Flat-Coated Retrievers (FCR; n = 289), which are two of the most affected dog breeds. Cases were selected from databases from different pathology services, and clinical information was retrospectively collected for each case. Localized HS was reported significantly more frequently in the FCR (60.6%) than in the BMD (39.2%), and disseminated HS was recorded significantly more frequently in the BMD (60.8%) than in the FCR (39.4%). Lameness was seen more often in FCR than in BMD, and the vast majority (78.1%) of LHS leading to lameness was located in the front legs in the FCR, while in the BMD, there was a more even distribution. BMD had significantly more often leukocytosis and thrombocytopenia, even corrected for the type of HS, than FCR. No significant difference in the frequency of anemia was recorded between BMD and FCR. In those dogs in which blood examination was performed, hypercalcemia was diagnosed in 15 BMD, while none of the FCR had hypercalcemia. The new information provided in this study can aid the diagnostic process and allow for prompt treatment recommendations.https://www.mdpi.com/2306-7381/9/9/498histiocytic sarcomaBernese Mountain DogFlat-Coated Retrieverclinical characteristicspathology |
| spellingShingle | Suzanne A. Erich Jane M. Dobson Erik Teske Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers Veterinary Sciences histiocytic sarcoma Bernese Mountain Dog Flat-Coated Retriever clinical characteristics pathology |
| title | Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers |
| title_full | Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers |
| title_fullStr | Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers |
| title_full_unstemmed | Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers |
| title_short | Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers |
| title_sort | comparison of the clinical characteristics of histiocytic sarcoma in bernese mountain dogs and flat coated retrievers |
| topic | histiocytic sarcoma Bernese Mountain Dog Flat-Coated Retriever clinical characteristics pathology |
| url | https://www.mdpi.com/2306-7381/9/9/498 |
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